RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes

An Song; Ya Fen Chen; Kimberlee Thamatrakoln; Theresa A. Storm; Alan M. Krensky

doi:10.1016/S1074-7613(00)80010-2

RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes

An Song, Ya Fen Chen, Kimberlee Thamatrakoln, Theresa A. Storm, Alan M. Krensky^*

^*Corresponding author for this work

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93 Scopus citations

Abstract

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.

Original language	English (US)
Pages (from-to)	93-103
Number of pages	11
Journal	Immunity
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S1074-7613(00)80010-2
State	Published - Jan 1999

Funding

We thank Carol Clayberger, Matthew Scott, and Mark Davis for critical review of the manuscript. We also thank Bruce W. Konicek, Allan Kaspar, and Katerina Drouvalakis for technical assistance. This work was supported by grants from the National Institutes of Health (DK35008 to A. M. K.). A. S. was supported by a training grant from National Institutes of Health (AI-07290) and is a Novartis Pharmaceutical fellow of National Kidney Foundation/American Society of Nephrology. Y. C. is a Sangstat fellow of American Society of Transplantation Physicians. A. M. K. is the Shelagh Galligan Professor and a Burroughs Wellcome Scholar in Experimental Therapeutics.

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1074-7613(00)80010-2

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title = "RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes",

abstract = "RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.",

author = "An Song and Chen, {Ya Fen} and Kimberlee Thamatrakoln and Storm, {Theresa A.} and Krensky, {Alan M.}",

note = "Funding Information: We thank Carol Clayberger, Matthew Scott, and Mark Davis for critical review of the manuscript. We also thank Bruce W. Konicek, Allan Kaspar, and Katerina Drouvalakis for technical assistance. This work was supported by grants from the National Institutes of Health (DK35008 to A. M. K.). A. S. was supported by a training grant from National Institutes of Health (AI-07290) and is a Novartis Pharmaceutical fellow of National Kidney Foundation/American Society of Nephrology. Y. C. is a Sangstat fellow of American Society of Transplantation Physicians. A. M. K. is the Shelagh Galligan Professor and a Burroughs Wellcome Scholar in Experimental Therapeutics.",

year = "1999",

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doi = "10.1016/S1074-7613(00)80010-2",

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AU - Storm, Theresa A.

AU - Krensky, Alan M.

N1 - Funding Information: We thank Carol Clayberger, Matthew Scott, and Mark Davis for critical review of the manuscript. We also thank Bruce W. Konicek, Allan Kaspar, and Katerina Drouvalakis for technical assistance. This work was supported by grants from the National Institutes of Health (DK35008 to A. M. K.). A. S. was supported by a training grant from National Institutes of Health (AI-07290) and is a Novartis Pharmaceutical fellow of National Kidney Foundation/American Society of Nephrology. Y. C. is a Sangstat fellow of American Society of Transplantation Physicians. A. M. K. is the Shelagh Galligan Professor and a Burroughs Wellcome Scholar in Experimental Therapeutics.

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N2 - RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.

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RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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