RFLAT-1: A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes

An Song, Ya Fen Chen, Kimberlee Thamatrakoln, Theresa A. Storm, Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalImmunity
Volume10
Issue number1
DOIs
StatePublished - Jan 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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