TY - JOUR
T1 - RFLAT-1
T2 - A new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes
AU - Song, An
AU - Chen, Ya Fen
AU - Thamatrakoln, Kimberlee
AU - Storm, Theresa A.
AU - Krensky, Alan M.
N1 - Funding Information:
We thank Carol Clayberger, Matthew Scott, and Mark Davis for critical review of the manuscript. We also thank Bruce W. Konicek, Allan Kaspar, and Katerina Drouvalakis for technical assistance. This work was supported by grants from the National Institutes of Health (DK35008 to A. M. K.). A. S. was supported by a training grant from National Institutes of Health (AI-07290) and is a Novartis Pharmaceutical fellow of National Kidney Foundation/American Society of Nephrology. Y. C. is a Sangstat fellow of American Society of Transplantation Physicians. A. M. K. is the Shelagh Galligan Professor and a Burroughs Wellcome Scholar in Experimental Therapeutics.
PY - 1999/1
Y1 - 1999/1
N2 - RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.
AB - RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells. RANTES is expressed late (3-5 days) after activation in T lymphocytes. Using expression cloning, we identified the first 'late' T lymphocyte associated transcription factor and named it 'RANTES Factor of Late Activated T Lymphocytes-1' (RFLAT-1). RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression. While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.
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U2 - 10.1016/S1074-7613(00)80010-2
DO - 10.1016/S1074-7613(00)80010-2
M3 - Article
C2 - 10023774
AN - SCOPUS:0033024375
SN - 1074-7613
VL - 10
SP - 93
EP - 103
JO - Immunity
JF - Immunity
IS - 1
ER -
