Rheumatoid factor interference with the latex agglutination test for fibrin degradation products

J. E. Rutstein, J. R. Holahan, R. M. Lyons, R. M. Pope

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The latex agglutination test for FDP is widely employed clinically to aid in the diagnosis of DIC and other conditions. Of sera containing RF, 93% demonstrated positive FDP latex agglutination tests. Reducing agents in all instances destroyed the RF agglutinating capability. Furthermore, 86% of sera positive for FDP and RF became FDP-negative following reduction. Therefore RF was responsible for false-positive FDP latex agglutination tests in the majority of patients. Reduction of patient sera is a rapid, simple method to distinguish a positive FDP test from a false-positive due to RF.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalThe Journal of laboratory and clinical medicine
Volume92
Issue number4
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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