RhoGTPases in stem cells

Hailei Yao; Xiaoyan Xie; Dongmei Wang; Xuetao Pei

doi:10.1007/s11434-007-0467-7

RhoGTPases in stem cells

Hailei Yao, Xiaoyan Xie, Dongmei Wang, Xuetao Pei^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed.

Original language	English (US)
Pages (from-to)	3025-3028
Number of pages	4
Journal	Chinese Science Bulletin
Volume	52
Issue number	22
DOIs	https://doi.org/10.1007/s11434-007-0467-7
State	Published - Nov 2007
Externally published	Yes

Keywords

Differentiation
Proliferation
RhoGTPases
Self-renewal
Stem cells

ASJC Scopus subject areas

General

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10.1007/s11434-007-0467-7

Cite this

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title = "RhoGTPases in stem cells",

abstract = "RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed.",

keywords = "Differentiation, Proliferation, RhoGTPases, Self-renewal, Stem cells",

author = "Hailei Yao and Xiaoyan Xie and Dongmei Wang and Xuetao Pei",

note = "Funding Information: Received March 26, 2007; accepted August 15, 2007 doi: 10.1007/s11434-007-0467-7 †Corresponding author (email: peixt@nic.bmi.ac.cn ) Supported by State 863 High Technology R&D Project of China (Grant No. 2006AA02A107) and the National Key Project for Basic Research of China (Grant No. 2005CB522702) Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = nov,

doi = "10.1007/s11434-007-0467-7",

language = "English (US)",

volume = "52",

pages = "3025--3028",

journal = "Science Bulletin",

issn = "2095-9273",

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AU - Yao, Hailei

AU - Xie, Xiaoyan

AU - Wang, Dongmei

AU - Pei, Xuetao

N1 - Funding Information: Received March 26, 2007; accepted August 15, 2007 doi: 10.1007/s11434-007-0467-7 †Corresponding author (email: peixt@nic.bmi.ac.cn ) Supported by State 863 High Technology R&D Project of China (Grant No. 2006AA02A107) and the National Key Project for Basic Research of China (Grant No. 2005CB522702) Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/11

Y1 - 2007/11

N2 - RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed.

AB - RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed.

KW - Differentiation

KW - Proliferation

KW - RhoGTPases

KW - Self-renewal

KW - Stem cells

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RhoGTPases in stem cells

Abstract

Keywords

ASJC Scopus subject areas

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