Rhythmogenic neuronal networks, emergent leaders, and k -cores

David J. Schwab, Robijn F. Bruinsma, Jack L. Feldman, Alex J. Levine

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Neuronal network behavior results from a combination of the dynamics of individual neurons and the connectivity of the network that links them together. We study a simplified model, based on the proposal of Feldman and Del Negro (FDN) [Nat. Rev. Neurosci. 7, 232 (2006)]10.1038/nrn1871, of the preBötzinger Complex, a small neuronal network that participates in the control of the mammalian breathing rhythm through periodic firing bursts. The dynamics of this randomly connected network of identical excitatory neurons differ from those of a uniformly connected one. Specifically, network connectivity determines the identity of emergent leader neurons that trigger the firing bursts. When neuronal desensitization is controlled by the number of input signals to the neurons (as proposed by FDN), the network's collective desensitization-required for successful burst termination-is mediated by k -core clusters of neurons.

Original languageEnglish (US)
Article number051911
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume82
Issue number5
DOIs
StatePublished - Nov 8 2010

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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