Ribosomal incorporation of cyclic β-amino acids into peptides using: In vitro translation

Joongoo Lee, Rafael Torres, Do Soon Kim, Michelle Byrom, Andrew D. Ellington, Michael C. Jewett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

Original languageEnglish (US)
Pages (from-to)5597-5600
Number of pages4
JournalChemical Communications
Volume56
Issue number42
DOIs
StatePublished - May 25 2020

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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