Right Ventricular Adaptation and Maladaptation in Chronic Pulmonary Arterial Hypertension

Stuart Rich

doi:10.1016/j.ccl.2012.03.004

Right Ventricular Adaptation and Maladaptation in Chronic Pulmonary Arterial Hypertension

Stuart Rich^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

The right ventricle (RV) is not well suited to chronic pressure overload and often fails to adequately compensate. Mechanisms that allow the RV to respond to acute pressure overload often become maladaptive and contribute to its failure, including the effects of pulmonary hypertension on RV myocardial perfusion, the influence of interventricular dependence on RV function, and metabolic shifts in the RV myocardium from fatty acid to glycolysis. Medications to treat pulmonary hypertension have focused on pulmonary vasodilatation. Their effects on RV function may determine their effectiveness. How new medications affect right ventricular performance must be addressed.

Original language	English (US)
Pages (from-to)	257-269
Number of pages	13
Journal	Cardiology Clinics
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.ccl.2012.03.004
State	Published - May 1 2012

Keywords

Adaptation
Heart failure
Maladaptation
Pulmonary hypertension
Right ventricle

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ccl.2012.03.004

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abstract = "The right ventricle (RV) is not well suited to chronic pressure overload and often fails to adequately compensate. Mechanisms that allow the RV to respond to acute pressure overload often become maladaptive and contribute to its failure, including the effects of pulmonary hypertension on RV myocardial perfusion, the influence of interventricular dependence on RV function, and metabolic shifts in the RV myocardium from fatty acid to glycolysis. Medications to treat pulmonary hypertension have focused on pulmonary vasodilatation. Their effects on RV function may determine their effectiveness. How new medications affect right ventricular performance must be addressed.",

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AB - The right ventricle (RV) is not well suited to chronic pressure overload and often fails to adequately compensate. Mechanisms that allow the RV to respond to acute pressure overload often become maladaptive and contribute to its failure, including the effects of pulmonary hypertension on RV myocardial perfusion, the influence of interventricular dependence on RV function, and metabolic shifts in the RV myocardium from fatty acid to glycolysis. Medications to treat pulmonary hypertension have focused on pulmonary vasodilatation. Their effects on RV function may determine their effectiveness. How new medications affect right ventricular performance must be addressed.

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KW - Heart failure

KW - Maladaptation

KW - Pulmonary hypertension

KW - Right ventricle

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Right Ventricular Adaptation and Maladaptation in Chronic Pulmonary Arterial Hypertension

Abstract

Keywords

ASJC Scopus subject areas

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