Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

Daniel B. Wright, Maria T. Proetto, Mollie A. Touve, Nathan Gianneschi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We report the one-pot aqueous phase synthesis of cisplatin drug loaded micellar nanoparticles using Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA). ROMPISA was used to generate a small library of nanoparticles to examine the effect of size and charge on their action as cytotoxic agents against human ovarian and cervical cancer cells in vitro. The results show that polymerization-induced self-assembly (PISA) can easily yield drug loaded nanoparticles in one step at high solids concentrations in water for formulation of drugs at cytotoxic levels.

Original languageEnglish (US)
Pages (from-to)2996-3000
Number of pages5
JournalPolymer Chemistry
Volume10
Issue number23
DOIs
StatePublished - Jun 21 2019

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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