@article{36e9230da75740068a6cd8fcc1baaff0,
title = "Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles",
abstract = "We report the one-pot aqueous phase synthesis of cisplatin drug loaded micellar nanoparticles using Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA). ROMPISA was used to generate a small library of nanoparticles to examine the effect of size and charge on their action as cytotoxic agents against human ovarian and cervical cancer cells in vitro. The results show that polymerization-induced self-assembly (PISA) can easily yield drug loaded nanoparticles in one step at high solids concentrations in water for formulation of drugs at cytotoxic levels.",
author = "Wright, {Daniel B.} and Proetto, {Maria T.} and Touve, {Mollie A.} and Gianneschi, {Nathan C.}",
note = "Funding Information: This research was conducted with support from DoD through a MURI from the Air Force Office of Scientific Research (FA-9550-16-1-0150) and a National Defense Science and Engineering Graduate (NDSEG) Fellowship, 32 CFR 168a, to M. A. T. This work made use of the BioCryo facility of Northwestern University{\textquoteright}s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); and the State of Illinois, through the IIN. Dr Swagat Sahu is kindly thanked for the quaternary amine phenyl norbornene dicarboximide. Ms Ziying Hu is thanked for zeta potential measurements. Apeiron Catalysts, Inc., are thanked for the generous donation of the aqueous initiator (Aquamet). Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
month = jun,
day = "21",
doi = "10.1039/c8py01539b",
language = "English (US)",
volume = "10",
pages = "2996--3000",
journal = "Polymer Chemistry",
issn = "1759-9954",
publisher = "Royal Society of Chemistry",
number = "23",
}
