Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure

Sara K. Pasquali, Bradley S. Marino, Anita Pudusseri, Gil Wernovsky, Stephen M. Paridon, Susan A. Walker, Meryl S. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Background: Over 25% of patients with congenital heart disease are obese (OB) or overweight (OW). Unique factors such as activity restriction and early feeding practices may play a role. We evaluated a high-risk cohort predisposed to early coronary artery disease due to past surgery involving coronary artery reimplantation. Methods: Patients at our institution who underwent the arterial switch or Ross operation were included. Data collection included chart review and activity and diet questionnaires. The proportion of OB/OW (body mass index ≥85%) was compared to national data. Factors associated with OB/OW were evaluated. Results: A total of 106 patients were enrolled. Median age was 14.2 years (6.0-19.9 years); 69% were male. Similar to national data, 31% were OB/OW (vs 31%, P = nonsignificant [NS]). There was no difference comparing OB/OW to normal-weight patients in activity restriction (cardiologist documented 27% vs 27%; parent reported 38% vs 42%, P = NS), activity level (9.8 hours/week [1.7-41.2] vs 11.5 [0.8-52.3], P = NS), or early feeding practices (formula vs breastfeeding, caloric fortification, tube feeding). OB/OW patients were more likely to have an OB parent (70% vs 37%, P = .01). Left ventricular mass index was higher in OB/OW patients (48.8 g/m2.7 [24.4-120.6] vs 37.7 g/m2.7 [16.5-85.1], P = .01). Conclusions: Nearly one third of ASO and Ross patients were OB/OW. Obese/overweight was not found to be related to activity restriction or early feeding practices, but was associated with parental obesity. Obese or OW patients had higher left ventricular mass. Obesity and associated comorbidities may pose additional cardiovascular risk in this unique population who underwent coronary artery reimplantation in childhood.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalAmerican Heart Journal
Volume158
Issue number3
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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