Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study

Elena B. Hawryluk; Danna Moustafa; Kelly K. Barry; Eman Bahrani; Diana B. Reusch; Meera Brahmbhatt; Lily Chen; Carrie C. Coughlin; Pedram Gerami; Ellen Haddock; Kristen Hook; Stephen R. Humphrey; Pei Chi Kao; Lacey L. Kruse; Leslie P. Lawley; Danny Mansour; Ashfaq A. Marghoob; Julie Nguyen; Thuy L. Phung; Elena Pope; Tom Raisanen; Sarah Robinson; Tova Rogers; Birgitta Schmidt; Gary Tran; Kate Travis; Zachary Wolner; Wendy B. London; Lawrence F. Eichenfield; Jennifer Huang

doi:10.1016/j.jaad.2023.10.067

Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study

Elena B. Hawryluk^*, Danna Moustafa, Kelly K. Barry, Eman Bahrani, Diana B. Reusch, Meera Brahmbhatt, Lily Chen, Carrie C. Coughlin, Pedram Gerami, Ellen Haddock, Kristen Hook, Stephen R. Humphrey, Pei Chi Kao, Lacey L. Kruse, Leslie P. Lawley, Danny Mansour, Ashfaq A. Marghoob, Julie Nguyen, Thuy L. Phung, Elena PopeTom Raisanen, Sarah Robinson, Tova Rogers, Birgitta Schmidt, Gary Tran, Kate Travis, Zachary Wolner, Wendy B. London, Lawrence F. Eichenfield, Jennifer Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Pediatric melanoma presents with distinct clinical features compared to adult disease. Objective: Characterize risk factors and negative outcomes in pediatric melanoma. Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers. Results: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls. Limitations: Retrospective nature, cohort size, control selection, and potential referral bias. Conclusion: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.

Original language	English (US)
Pages (from-to)	716-726
Number of pages	11
Journal	Journal of the American Academy of Dermatology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.jaad.2023.10.067
State	Published - Apr 2024

Funding

Funding sources: 2019 Pediatric Dermatology Research Alliance Study Support Grant and 2017 Society for Pediatric Dermatology, Pediatric Dermatology Research Alliance Pilot Award. EBH received support from the Dermatology Foundation and the Harvard Medical School Eleanor and Miles Shore Fellowship Award.

Keywords

melanoma
oncology
pediatric dermatology
pediatric melanoma

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaad.2023.10.067

Cite this

Hawryluk, E. B., Moustafa, D., Barry, K. K., Bahrani, E., Reusch, D. B., Brahmbhatt, M., Chen, L., Coughlin, C. C., Gerami, P., Haddock, E., Hook, K., Humphrey, S. R., Kao, P. C., Kruse, L. L., Lawley, L. P., Mansour, D., Marghoob, A. A., Nguyen, J., Phung, T. L., ... Huang, J. (2024). Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study. Journal of the American Academy of Dermatology, 90(4), 716-726. https://doi.org/10.1016/j.jaad.2023.10.067

@article{4791e07bd6a147ccb871063910af1c49,

title = "Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study",

abstract = "Background: Pediatric melanoma presents with distinct clinical features compared to adult disease. Objective: Characterize risk factors and negative outcomes in pediatric melanoma. Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers. Results: Melanoma was diagnosed in 317 patients, 73\% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31\%) and superficial spreading (26\%) subtypes were most common and 11\% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68\% of cases and positive in 46\%. Fatality was observed in 7\% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls. Limitations: Retrospective nature, cohort size, control selection, and potential referral bias. Conclusion: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.",

keywords = "melanoma, oncology, pediatric dermatology, pediatric melanoma",

author = "Hawryluk, \{Elena B.\} and Danna Moustafa and Barry, \{Kelly K.\} and Eman Bahrani and Reusch, \{Diana B.\} and Meera Brahmbhatt and Lily Chen and Coughlin, \{Carrie C.\} and Pedram Gerami and Ellen Haddock and Kristen Hook and Humphrey, \{Stephen R.\} and Kao, \{Pei Chi\} and Kruse, \{Lacey L.\} and Lawley, \{Leslie P.\} and Danny Mansour and Marghoob, \{Ashfaq A.\} and Julie Nguyen and Phung, \{Thuy L.\} and Elena Pope and Tom Raisanen and Sarah Robinson and Tova Rogers and Birgitta Schmidt and Gary Tran and Kate Travis and Zachary Wolner and London, \{Wendy B.\} and Eichenfield, \{Lawrence F.\} and Jennifer Huang",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = apr,

doi = "10.1016/j.jaad.2023.10.067",

language = "English (US)",

volume = "90",

pages = "716--726",

journal = "Journal of the American Academy of Dermatology",

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Hawryluk, EB, Moustafa, D, Barry, KK, Bahrani, E, Reusch, DB, Brahmbhatt, M, Chen, L, Coughlin, CC, Gerami, P, Haddock, E, Hook, K, Humphrey, SR, Kao, PC, Kruse, LL, Lawley, LP, Mansour, D, Marghoob, AA, Nguyen, J, Phung, TL, Pope, E, Raisanen, T, Robinson, S, Rogers, T, Schmidt, B, Tran, G, Travis, K, Wolner, Z, London, WB, Eichenfield, LF & Huang, J 2024, 'Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study', Journal of the American Academy of Dermatology, vol. 90, no. 4, pp. 716-726. https://doi.org/10.1016/j.jaad.2023.10.067

TY - JOUR

T1 - Risk factors and outcomes of melanoma in children and adolescents

T2 - A retrospective multicenter study

AU - Hawryluk, Elena B.

AU - Moustafa, Danna

AU - Barry, Kelly K.

AU - Bahrani, Eman

AU - Reusch, Diana B.

AU - Brahmbhatt, Meera

AU - Chen, Lily

AU - Coughlin, Carrie C.

AU - Gerami, Pedram

AU - Haddock, Ellen

AU - Hook, Kristen

AU - Humphrey, Stephen R.

AU - Kao, Pei Chi

AU - Kruse, Lacey L.

AU - Lawley, Leslie P.

AU - Mansour, Danny

AU - Marghoob, Ashfaq A.

AU - Nguyen, Julie

AU - Phung, Thuy L.

AU - Pope, Elena

AU - Raisanen, Tom

AU - Robinson, Sarah

AU - Rogers, Tova

AU - Schmidt, Birgitta

AU - Tran, Gary

AU - Travis, Kate

AU - Wolner, Zachary

AU - London, Wendy B.

AU - Eichenfield, Lawrence F.

AU - Huang, Jennifer

PY - 2024/4

Y1 - 2024/4

N2 - Background: Pediatric melanoma presents with distinct clinical features compared to adult disease. Objective: Characterize risk factors and negative outcomes in pediatric melanoma. Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers. Results: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls. Limitations: Retrospective nature, cohort size, control selection, and potential referral bias. Conclusion: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.

AB - Background: Pediatric melanoma presents with distinct clinical features compared to adult disease. Objective: Characterize risk factors and negative outcomes in pediatric melanoma. Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers. Results: Melanoma was diagnosed in 317 patients, 73% of whom were diagnosed in adolescence (age ≥11). Spitzoid (31%) and superficial spreading (26%) subtypes were most common and 11% of cases arose from congenital nevi. Sentinel lymph node biopsy was performed in 68% of cases and positive in 46%. Fatality was observed in 7% of cases. Adolescent patients with melanoma were more likely to have family history of melanoma (P = .046) compared to controls. Limitations: Retrospective nature, cohort size, control selection, and potential referral bias. Conclusion: Pediatric melanoma has diverse clinical presentations. Better understanding of these cases and outcomes may facilitate improved risk stratification of pediatric melanoma.

KW - melanoma

KW - oncology

KW - pediatric dermatology

KW - pediatric melanoma

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AN - SCOPUS:85181126235

SN - 0190-9622

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SP - 716

EP - 726

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 4

ER -

Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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