Risk Factors, Diagnosis, Management, and Outcome of Splanchnic Vein Thrombosis: A Retrospective Analysis

Benjamin A. Derman, Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objectives This study aims to determine the risk factors, diagnostic methods employed, treatment modalities, and outcome in patients with splanchnic vein thrombosis (SVT). Methods A retrospective chart review of patients, age 18 to 90 years, diagnosed with SVT at a single institution from January 1, 2010 to November 10, 2012. They were grouped as portal vein thrombosis (PVT)-including those combined with splenic vein thrombosis (SPVT) or mesenteric vein thrombosis (MVT)--and Budd-Chiari syndrome (BCS). Results Overall 246 SVT patients were identified, including 225 PVT and 21 BCS. Risk factors were liver disease, upper abdominal (regional) cancer and surgery, pancreatitis, and hereditary thrombophilia. The most common symptom was abdominal pain and most patients had abnormal liver function. Among those tested, the JAK2 V617F mutation was present in only 20% of the patients with PVT and 14% of the patients with BCS. Most patients were diagnosed by computed tomography. Anticoagulants were given to 30% of the patients with PVT and to 60% of the patients with BCS, with recurrence of SVT in 15% of the patients with PVT and 24% of the patients with BCS, regardless of anticoagulation. Conclusion As compared with published literature on SVT, we found a higher incidence of regional cancer and surgery and a lower incidence of the JAK2 V617F mutation.

Original languageEnglish (US)
Article number02191
Pages (from-to)503-513
Number of pages11
JournalSeminars in thrombosis and hemostasis
Volume41
Issue number5
DOIs
StatePublished - Jun 16 2015

Keywords

  • Budd-Chiari syndrome
  • hepatic vein
  • mesenteric veins
  • portal vein
  • splenic vein

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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