Risk factors for cardiovascular disease in children on maintenance dialysis

Blanche Chavers*, H. William Schnaper

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Cardiovascular disease mortality is high in children on maintenance dialysis, accounting for about 25% of patient deaths. Cardiovascular-related mortality rates for children on dialysis are higher than for children with successful kidney transplants. Data on the long-term consequences of risk factors for cardiovascular disease are lacking for pediatric end-stage renal disease patients. This article reviews pediatric data pertaining to the following risk factors: anemia, hypertension, hyperlipidemia, left ventricular hypertrophy, abnormal calcium-phosphorus metabolism, and hyperhomocysteinemia. The potential relationship of end-stage renal disease to the etiology of several functional disorders of the cardiovascular system is discussed. Clinical studies are needed to assess the prevalence of cardiovascular disease and of cardiovascular disease risk factors in the pediatric end-stage renal disease population. Possible preventive and therapeutic guidelines need to be developed for at-risk children on maintenance dialysis.

Original languageEnglish (US)
Pages (from-to)180-190
Number of pages11
JournalAdvances in Renal Replacement Therapy
Volume8
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Cardiovascular disease
  • Dialysis
  • End-stage renal disease
  • Pediatric
  • Risk factors

ASJC Scopus subject areas

  • Nephrology

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