Risk Factors for CKD Progression: Overview of Findings from the CRIC Study

CRIC Study Investigators, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

Research output: Contribution to journalArticlepeer-review

Abstract

The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.

Original languageEnglish (US)
Pages (from-to)648-659
Number of pages12
JournalClinical journal of the American Society of Nephrology : CJASN
Volume16
Issue number4
DOIs
StatePublished - Apr 7 2021

Keywords

  • chronic kidney disease
  • progression of chronic renal failure
  • risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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