Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures

Sigita Plioplys*, Julia Doss, Prabha Siddarth, Brenda Bursch, Tatiana Falcone, Marcy Forgey, Kyle Hinman, W. Curt Lafrance, Rebecca Laptook, Richard J. Shaw, Deborah M. Weisbrot, Matthew D. Willis, Rochelle Caplan

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalSeizure
Volume38
DOIs
StatePublished - May 1 2016

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Keywords

  • Anxiety
  • Children
  • Depression
  • Psychogenic
  • Psychopathology
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Plioplys, S., Doss, J., Siddarth, P., Bursch, B., Falcone, T., Forgey, M., Hinman, K., Lafrance, W. C., Laptook, R., Shaw, R. J., Weisbrot, D. M., Willis, M. D., & Caplan, R. (2016). Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. Seizure, 38, 32-37. https://doi.org/10.1016/j.seizure.2016.03.012