TY - JOUR
T1 - Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures
AU - Plioplys, Sigita
AU - Doss, Julia
AU - Siddarth, Prabha
AU - Bursch, Brenda
AU - Falcone, Tatiana
AU - Forgey, Marcy
AU - Hinman, Kyle
AU - Lafrance, W. Curt
AU - Laptook, Rebecca
AU - Shaw, Richard J.
AU - Weisbrot, Deborah M.
AU - Willis, Matthew D.
AU - Caplan, Rochelle
N1 - Funding Information:
This study was supported by a grant from the Epilepsy Foundation, research funds from the Department of Child and Adolescent Psychiatry, Feinberg School of Medicine at Northwestern University , and a junior faculty career development award from the UCLA Semel Institute for Neuroscience and Human Behavior .
Publisher Copyright:
© 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.
AB - Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.
KW - Anxiety
KW - Children
KW - Depression
KW - Psychogenic
KW - Psychopathology
KW - Seizures
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U2 - 10.1016/j.seizure.2016.03.012
DO - 10.1016/j.seizure.2016.03.012
M3 - Article
C2 - 27085102
AN - SCOPUS:84963653967
VL - 38
SP - 32
EP - 37
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
SN - 1059-1311
ER -