Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures

Sigita Plioplys; Julia Doss; Prabha Siddarth; Brenda Bursch; Tatiana Falcone; Marcy Forgey; Kyle Hinman; W. Curt Lafrance; Rebecca Laptook; Richard J. Shaw; Deborah M. Weisbrot; Matthew D. Willis; Rochelle Caplan

doi:10.1016/j.seizure.2016.03.012

Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures

Sigita Plioplys^*, Julia Doss, Prabha Siddarth, Brenda Bursch, Tatiana Falcone, Marcy Forgey, Kyle Hinman, W. Curt Lafrance, Rebecca Laptook, Richard J. Shaw, Deborah M. Weisbrot, Matthew D. Willis, Rochelle Caplan

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.

Original language	English (US)
Pages (from-to)	32-37
Number of pages	6
Journal	Seizure
Volume	38
DOIs	https://doi.org/10.1016/j.seizure.2016.03.012
State	Published - May 1 2016

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Keywords

Anxiety
Children
Depression
Psychogenic
Psychopathology
Seizures

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

Plioplys, S., Doss, J., Siddarth, P., Bursch, B., Falcone, T., Forgey, M., Hinman, K., Lafrance, W. C., Laptook, R., Shaw, R. J., Weisbrot, D. M., Willis, M. D., & Caplan, R. (2016). Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. Seizure, 38, 32-37. https://doi.org/10.1016/j.seizure.2016.03.012

Plioplys, Sigita ; Doss, Julia ; Siddarth, Prabha ; Bursch, Brenda ; Falcone, Tatiana ; Forgey, Marcy ; Hinman, Kyle ; Lafrance, W. Curt ; Laptook, Rebecca ; Shaw, Richard J. ; Weisbrot, Deborah M. ; Willis, Matthew D. ; Caplan, Rochelle. / Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. In: Seizure. 2016 ; Vol. 38. pp. 32-37.

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abstract = "Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.",

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author = "Sigita Plioplys and Julia Doss and Prabha Siddarth and Brenda Bursch and Tatiana Falcone and Marcy Forgey and Kyle Hinman and Lafrance, {W. Curt} and Rebecca Laptook and Shaw, {Richard J.} and Weisbrot, {Deborah M.} and Willis, {Matthew D.} and Rochelle Caplan",

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Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures. / Plioplys, Sigita; Doss, Julia; Siddarth, Prabha; Bursch, Brenda; Falcone, Tatiana; Forgey, Marcy; Hinman, Kyle; Lafrance, W. Curt; Laptook, Rebecca; Shaw, Richard J.; Weisbrot, Deborah M.; Willis, Matthew D.; Caplan, Rochelle.

In: Seizure, Vol. 38, 01.05.2016, p. 32-37.

Research output: Contribution to journal › Article

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T1 - Risk factors for comorbid psychopathology in youth with psychogenic nonepileptic seizures

AU - Plioplys, Sigita

AU - Doss, Julia

AU - Siddarth, Prabha

AU - Bursch, Brenda

AU - Falcone, Tatiana

AU - Forgey, Marcy

AU - Hinman, Kyle

AU - Lafrance, W. Curt

AU - Laptook, Rebecca

AU - Shaw, Richard J.

AU - Weisbrot, Deborah M.

AU - Willis, Matthew D.

AU - Caplan, Rochelle

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N2 - Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.

AB - Purpose To examine the risk factors for internalizing (anxiety, depression) and posttraumatic stress (PTSD) disorders, somatization, and anxiety sensitivity (AS) in youth with psychogenic non-epileptic seizures (PNES). Methods 55 probands with PNES and 35 siblings, aged 8-18 years, underwent a psychiatric interview, cognitive and language testing, and completed somatization and AS questionnaires. Parents provided the subjects' medical, psychiatric, family, and adversity history information. Results The risk factors for the probands' internalizing disorders (girls, older age of PNES onset), somatization (older age, epilepsy), and anxiety sensitivity (girls, adversities) differed from their siblings. The risk factors in the siblings, however, were similar to the general pediatric population. Proband depression was unrelated to the study's risk variables while PTSD was significantly associated with female gender and lower Full Scale IQ. Conclusions Knowledge about the specificity of the risk factors for comorbid psychopathology in youth with PNES might facilitate their early identification and treatment.

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10.1016/j.seizure.2016.03.012