Risk factors for hypogonadism in young men with erectile dysfunction

I. Shen Huang, Daniel J. Mazur, Barbara E. Kahn, Mary Kate Keeter, Anuj S. Desai, Kevin Lewis, Alexander J. Tatem, Marah C. Hehemann, Robert E. Brannigan, Nelson E. Bennett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The objective of this study is to evaluate the hormone profile of young men with the chief complaint of erectile dysfunction (ED) and determine the comorbidities in this population. Methods: A retrospective chart review of men aged 18 to 40 years who presented with ED and had a hormone evaluation but without prior medication for hormone manipulation from 2002 to 2016 was performed at a tertiary care institution. Data were obtained on demographics, comorbidities, medications, and hormonal evaluations. Results: A total of 2292 men with ED were identified and 2130 of them received testosterone level evaluation. The most common comorbidities that men were actively being treated for were depression (22.3%), anxiety (16.1%), hypertension (15.6%), diabetes (7.2%), cancer (6.2%), and cardiovascular disease (3.3%). The average total testosterone level was 368 ± 160 ng/dL; 10.7% of men had hypogonadism. Multivariate analysis demonstrated age, body mass index (BMI), depression, and cancer predicted a hypogonadal status. Patients with BMI > 28.2 kg/m2, age > 34 years, cancer diagnosis, or depression were 3.350-fold, 1.447-fold, 2.317-fold, or 1.420-fold more likely to be diagnosed hypogonadal than nonoverweight, age ≤ 34 years, noncancer, or nondepressive patients. Conclusion: The majority of men under the age of 40 with ED exhibit a normal hormonal milieu. Young ED men with BMI > 28.2 kg/m2, age >34 years, cancer diagnosis, or depression are at risk for hypogonadism.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalJournal of the Chinese Medical Association
Issue number6
StatePublished - Jan 1 2019


  • Erectile dysfunction
  • Hormone
  • Hypogonadism
  • Men

ASJC Scopus subject areas

  • General Medicine


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