Risk factors of intracranial cerebral atherosclerosis among asymptomatics

Hee Joon Bae; Juneyoung Lee; Jong Moo Park; Ohyun Kwon; Ja Seong Koo; Byung Kun Kim; Dilip K. Pandey

doi:10.1159/000106982

Risk factors of intracranial cerebral atherosclerosis among asymptomatics

Hee Joon Bae^*, Juneyoung Lee, Jong Moo Park, Ohyun Kwon, Ja Seong Koo, Byung Kun Kim, Dilip K. Pandey

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Background: Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics. Methods: Data from a consecutive series of 1,208 subjects aged ≥40 years, with no history of stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role of classic risk factors was assessed in the presence and severity of asymptomatic ICAS, which was determined by TCD. Results: Regarding the presence of ICAS, the adjusted odds ratios (95% confidence intervals) were as follows: 1.22 (1.08-1.37) for every 10-year increase in age, 1.44 (1.08-1.91) for hypertension and 1.86 (1.33-2.59) for diabetes mellitus. No significant association was observed with regard to male sex, smoking or hyperlipidemia. Conclusion: The findings suggest that age, hypertension and diabetes mellitus are significant risk factors for ICAS in asymptomatic populations.

Original language	English (US)
Pages (from-to)	355-360
Number of pages	6
Journal	Cerebrovascular Diseases
Volume	24
Issue number	4
DOIs	https://doi.org/10.1159/000106982
State	Published - Sep 2007

Keywords

Intracranial arterial disease
Intracranial arteriosclerosis, risk factors
Transcranial Doppler

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000106982

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@article{ddf48ed2ab77410cb703c1bd2bd634a0,

title = "Risk factors of intracranial cerebral atherosclerosis among asymptomatics",

abstract = "Background: Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics. Methods: Data from a consecutive series of 1,208 subjects aged ≥40 years, with no history of stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role of classic risk factors was assessed in the presence and severity of asymptomatic ICAS, which was determined by TCD. Results: Regarding the presence of ICAS, the adjusted odds ratios (95\% confidence intervals) were as follows: 1.22 (1.08-1.37) for every 10-year increase in age, 1.44 (1.08-1.91) for hypertension and 1.86 (1.33-2.59) for diabetes mellitus. No significant association was observed with regard to male sex, smoking or hyperlipidemia. Conclusion: The findings suggest that age, hypertension and diabetes mellitus are significant risk factors for ICAS in asymptomatic populations.",

keywords = "Intracranial arterial disease, Intracranial arteriosclerosis, risk factors, Transcranial Doppler",

author = "Bae, \{Hee Joon\} and Juneyoung Lee and Park, \{Jong Moo\} and Ohyun Kwon and Koo, \{Ja Seong\} and Kim, \{Byung Kun\} and Pandey, \{Dilip K.\}",

year = "2007",

month = sep,

doi = "10.1159/000106982",

language = "English (US)",

volume = "24",

pages = "355--360",

journal = "Cerebrovascular Diseases",

issn = "1015-9770",

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TY - JOUR

T1 - Risk factors of intracranial cerebral atherosclerosis among asymptomatics

AU - Bae, Hee Joon

AU - Lee, Juneyoung

AU - Park, Jong Moo

AU - Kwon, Ohyun

AU - Koo, Ja Seong

AU - Kim, Byung Kun

AU - Pandey, Dilip K.

PY - 2007/9

Y1 - 2007/9

N2 - Background: Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics. Methods: Data from a consecutive series of 1,208 subjects aged ≥40 years, with no history of stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role of classic risk factors was assessed in the presence and severity of asymptomatic ICAS, which was determined by TCD. Results: Regarding the presence of ICAS, the adjusted odds ratios (95% confidence intervals) were as follows: 1.22 (1.08-1.37) for every 10-year increase in age, 1.44 (1.08-1.91) for hypertension and 1.86 (1.33-2.59) for diabetes mellitus. No significant association was observed with regard to male sex, smoking or hyperlipidemia. Conclusion: The findings suggest that age, hypertension and diabetes mellitus are significant risk factors for ICAS in asymptomatic populations.

AB - Background: Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics. Methods: Data from a consecutive series of 1,208 subjects aged ≥40 years, with no history of stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role of classic risk factors was assessed in the presence and severity of asymptomatic ICAS, which was determined by TCD. Results: Regarding the presence of ICAS, the adjusted odds ratios (95% confidence intervals) were as follows: 1.22 (1.08-1.37) for every 10-year increase in age, 1.44 (1.08-1.91) for hypertension and 1.86 (1.33-2.59) for diabetes mellitus. No significant association was observed with regard to male sex, smoking or hyperlipidemia. Conclusion: The findings suggest that age, hypertension and diabetes mellitus are significant risk factors for ICAS in asymptomatic populations.

KW - Intracranial arterial disease

KW - Intracranial arteriosclerosis, risk factors

KW - Transcranial Doppler

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U2 - 10.1159/000106982

DO - 10.1159/000106982

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SN - 1015-9770

VL - 24

SP - 355

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JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

IS - 4

ER -

Risk factors of intracranial cerebral atherosclerosis among asymptomatics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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