TY - JOUR
T1 - Risk for bipolar spectrum disorders associated with positive urgency and orbitofrontal cortical grey matter volume
AU - Carroll, Ann L.
AU - Damme, Katherine S.F.
AU - Alloy, Lauren B.
AU - Bart, Corinne P.
AU - Ng, Tommy H.
AU - Titone, Madison K.
AU - Chein, Jason
AU - Cichocki, Anna C.
AU - Armstrong, Casey C.
AU - Nusslock, Robin
N1 - Funding Information:
This research was supported by National Institute of Mental Health (NIMH) Grant MH077908 and MH126911 to Lauren B. Alloy. Preparation of the manuscript also was supported by NIMH Grant MH100117 to Robin Nusslock and National Institute of Health (NIH) grant T32 NS047987 to Ann L. Carroll. Funding sources did not have a role in the conduct of the study or the preparation and submission of the article.
Publisher Copyright:
© 2022
PY - 2022/1
Y1 - 2022/1
N2 - Bipolar spectrum disorders (BSDs) are associated with reward hypersensitivity, impulsivity, and structural abnormalities within the brain's reward system. Using a behavioral high-risk study design based on reward sensitivity, this paper had two primary objectives: 1) investigate whether elevated positive urgency, the tendency to act rashly when experiencing extreme positive affect, is a risk for or correlate of BSDs, and 2) examine the nature of the relationship between positive urgency and grey matter volume in fronto-striatal reward regions, among individuals at differential risk for BSD. Young adults (ages 18–28) screened to be moderately reward sensitive (MReward; N = 42), highly reward sensitive (HReward; N = 48), or highly reward sensitive with a lifetime BSD (HReward + BSD; N = 32) completed a structural MRI scan and the positive urgency subscale of the UPPS-P scale. Positive urgency scores varied with BSD risk (MReward < HReward < HReward + BSD; ps≤0.05), and positive urgency interacted with BSD risk group in predicting lateral OFC volume (p <.001). Specifically, the MReward group showed a negative relationship between positive urgency and lateral OFC volume. By contrast, there was no relationship between positive urgency and lateral OFC grey matter volume among the HReward and HReward + BSD groups. The results suggest that heightened trait positive urgency is a pre-existing vulnerability for BSD that worsens with illness onset, and there is a distinct relationship between positive urgency and lateral OFC volume among individuals at high versus low risk for BSD. These findings have implications for understanding the expression and development of impulsivity in BSDs.
AB - Bipolar spectrum disorders (BSDs) are associated with reward hypersensitivity, impulsivity, and structural abnormalities within the brain's reward system. Using a behavioral high-risk study design based on reward sensitivity, this paper had two primary objectives: 1) investigate whether elevated positive urgency, the tendency to act rashly when experiencing extreme positive affect, is a risk for or correlate of BSDs, and 2) examine the nature of the relationship between positive urgency and grey matter volume in fronto-striatal reward regions, among individuals at differential risk for BSD. Young adults (ages 18–28) screened to be moderately reward sensitive (MReward; N = 42), highly reward sensitive (HReward; N = 48), or highly reward sensitive with a lifetime BSD (HReward + BSD; N = 32) completed a structural MRI scan and the positive urgency subscale of the UPPS-P scale. Positive urgency scores varied with BSD risk (MReward < HReward < HReward + BSD; ps≤0.05), and positive urgency interacted with BSD risk group in predicting lateral OFC volume (p <.001). Specifically, the MReward group showed a negative relationship between positive urgency and lateral OFC volume. By contrast, there was no relationship between positive urgency and lateral OFC grey matter volume among the HReward and HReward + BSD groups. The results suggest that heightened trait positive urgency is a pre-existing vulnerability for BSD that worsens with illness onset, and there is a distinct relationship between positive urgency and lateral OFC volume among individuals at high versus low risk for BSD. These findings have implications for understanding the expression and development of impulsivity in BSDs.
KW - Bipolar spectrum disorder (BSD)
KW - Grey matter volume
KW - Orbitofrontal cortex (OFC)
KW - Positive urgency
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U2 - 10.1016/j.nicl.2022.103225
DO - 10.1016/j.nicl.2022.103225
M3 - Article
C2 - 36242853
AN - SCOPUS:85139875045
SN - 2213-1582
VL - 36
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103225
ER -