Risk of Anaphylaxis with Repeated Courses of Rasburicase: A Research on Adverse Drug Events and Reports (RADAR) Project

Katherine C. Allen, Amanda H. Champlain, Jonathan A. Cotliar, Steven M. Belknap, Dennis P. West*, Jayesh Mehta, Steven M. Trifilio

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Background: Rasburicase, a recombinant urate oxidase, is used to rapidly metabolize uric acid in patients with hyperuricaemia. Rasburicase is an immunogenic therapeutic protein, which has been shown to elicit antibody response in 64 % of healthy volunteers within 1–6 weeks after the initial course, with persistent antibodies for over 1 year. Drug labelling indicates that anaphylaxis rarely occurs (in <1 % of patients) after a single course of therapy with rasburicase, but there are no data available on the incidence of anaphylaxis in patients receiving a subsequent rasburicase course.

Objective: The objective of this study was to determine the incidence of anaphylaxis after multiple treatment courses of rasburicase.

Methods: A retrospective chart review was performed on 97 consecutively treated patients who received repeated courses of rasburicase for hyperuricaemia.

Results: None of the 97 patients who were reviewed experienced anaphylaxis during the first rasburicase course; however, six patients (6.2 %) experienced anaphylaxis during a subsequent rasburicase treatment course (p = 0.03).

Conclusion: Anaphylaxis after a second course of rasburicase appears to occur more frequently than described in the US Food and Drug Administration-approved package insert for initial treatment courses. Given the serious nature of anaphylactic events, caution is advised when administering repeated courses of rasburicase.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalDrug Safety
Volume38
Issue number2
DOIs
StatePublished - Feb 14 2015

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

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