Abstract
Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 624-631 |
| Number of pages | 8 |
| Journal | American journal of perinatology |
| Volume | 36 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- family history
- inheritance
- ischemic placental disease
- placental abruption
- preeclampsia
- small for gestational age infant
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
}
Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. / Ananth, Cande V.; Jablonski, Kathleen; Myatt, Leslie; Roberts, James M.; Tita, Alan T.N.; Leveno, Kenneth J.; Reddy, Uma M.; Varner, Michael W.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M; Ramin, Susan M.; Carpenter, Marshall W.; Samuels, Philip; Sciscione, Anthony; Tolosa, Jorge E.; Saade, George; Sorokin, Yoram.
In: American journal of perinatology, Vol. 36, No. 6, 01.01.2019, p. 624-631.Research output: Contribution to journal › Article
TY - JOUR
T1 - Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia
AU - Ananth, Cande V.
AU - Jablonski, Kathleen
AU - Myatt, Leslie
AU - Roberts, James M.
AU - Tita, Alan T.N.
AU - Leveno, Kenneth J.
AU - Reddy, Uma M.
AU - Varner, Michael W.
AU - Thorp, John M.
AU - Mercer, Brian M.
AU - Peaceman, Alan M
AU - Ramin, Susan M.
AU - Carpenter, Marshall W.
AU - Samuels, Philip
AU - Sciscione, Anthony
AU - Tolosa, Jorge E.
AU - Saade, George
AU - Sorokin, Yoram
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.
AB - Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.
KW - family history
KW - inheritance
KW - ischemic placental disease
KW - placental abruption
KW - preeclampsia
KW - small for gestational age infant
UR - http://www.scopus.com/inward/record.url?scp=85065330688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065330688&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1672177
DO - 10.1055/s-0038-1672177
M3 - Article
C2 - 30282103
AN - SCOPUS:85065330688
VL - 36
SP - 624
EP - 631
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 6
ER -