Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Cande V. Ananth; Kathleen Jablonski; Leslie Myatt; James M. Roberts; Alan T.N. Tita; Kenneth J. Leveno; Uma M. Reddy; Michael W. Varner; John M. Thorp; Brian M. Mercer; Alan M. Peaceman; Susan M. Ramin; Marshall W. Carpenter; Philip Samuels; Anthony Sciscione; Jorge E. Tolosa; George Saade; Yoram Sorokin

doi:10.1055/s-0038-1672177

Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Cande V. Ananth^*, Kathleen Jablonski, Leslie Myatt, James M. Roberts, Alan T.N. Tita, Kenneth J. Leveno, Uma M. Reddy, Michael W. Varner, John M. Thorp, Brian M. Mercer, Alan M. Peaceman, Susan M. Ramin, Marshall W. Carpenter, Philip Samuels, Anthony Sciscione, Jorge E. Tolosa, George Saade, Yoram Sorokin

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

Original language	English (US)
Pages (from-to)	624-631
Number of pages	8
Journal	American journal of perinatology
Volume	36
Issue number	6
DOIs	https://doi.org/10.1055/s-0038-1672177
State	Published - 2019

Keywords

family history
inheritance
ischemic placental disease
placental abruption
preeclampsia
small for gestational age infant

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/s-0038-1672177

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Ananth, C. V., Jablonski, K., Myatt, L., Roberts, J. M., Tita, A. T. N., Leveno, K. J., Reddy, U. M., Varner, M. W., Thorp, J. M., Mercer, B. M., Peaceman, A. M., Ramin, S. M., Carpenter, M. W., Samuels, P., Sciscione, A., Tolosa, J. E., Saade, G., & Sorokin, Y. (2019). Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. American journal of perinatology, 36(6), 624-631. https://doi.org/10.1055/s-0038-1672177

Ananth, Cande V. ; Jablonski, Kathleen ; Myatt, Leslie ; Roberts, James M. ; Tita, Alan T.N. ; Leveno, Kenneth J. ; Reddy, Uma M. ; Varner, Michael W. ; Thorp, John M. ; Mercer, Brian M. ; Peaceman, Alan M. ; Ramin, Susan M. ; Carpenter, Marshall W. ; Samuels, Philip ; Sciscione, Anthony ; Tolosa, Jorge E. ; Saade, George ; Sorokin, Yoram. / Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. In: American journal of perinatology. 2019 ; Vol. 36, No. 6. pp. 624-631.

@article{7588fffec5a84b21a060709d7302f5de,

title = "Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia",

abstract = "Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.",

keywords = "family history, inheritance, ischemic placental disease, placental abruption, preeclampsia, small for gestational age infant",

author = "Ananth, {Cande V.} and Kathleen Jablonski and Leslie Myatt and Roberts, {James M.} and Tita, {Alan T.N.} and Leveno, {Kenneth J.} and Reddy, {Uma M.} and Varner, {Michael W.} and Thorp, {John M.} and Mercer, {Brian M.} and Peaceman, {Alan M.} and Ramin, {Susan M.} and Carpenter, {Marshall W.} and Philip Samuels and Anthony Sciscione and Tolosa, {Jorge E.} and George Saade and Yoram Sorokin",

note = "Funding Information: The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD34208, HD27869, HD40485, HD40560, HD40544, HD34116, HD40512, HD21410, HD40545, HD40500, HD27915, HD34136, HD27860, HD53118, HD53097, HD27917, and HD36801); the National Heart, Lung, and Blood Institute; and the National Center for Research Resources (M01 RR00080, UL1 RR024153, and UL1 RR024989). Comments and views of the authors do not necessarily represent the views of the NIH. Publisher Copyright: {\textcopyright} 2019 by Thieme Medical Publishers, Inc.",

year = "2019",

doi = "10.1055/s-0038-1672177",

language = "English (US)",

volume = "36",

pages = "624--631",

journal = "American Journal of Perinatology",

issn = "0735-1631",

publisher = "Thieme Medical Publishers",

number = "6",

}

Ananth, CV, Jablonski, K, Myatt, L, Roberts, JM, Tita, ATN, Leveno, KJ, Reddy, UM, Varner, MW, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Samuels, P, Sciscione, A, Tolosa, JE, Saade, G & Sorokin, Y 2019, 'Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia', American journal of perinatology, vol. 36, no. 6, pp. 624-631. https://doi.org/10.1055/s-0038-1672177

Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. / Ananth, Cande V.; Jablonski, Kathleen; Myatt, Leslie; Roberts, James M.; Tita, Alan T.N.; Leveno, Kenneth J.; Reddy, Uma M.; Varner, Michael W.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M.; Ramin, Susan M.; Carpenter, Marshall W.; Samuels, Philip; Sciscione, Anthony; Tolosa, Jorge E.; Saade, George; Sorokin, Yoram.

In: American journal of perinatology, Vol. 36, No. 6, 2019, p. 624-631.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

AU - Ananth, Cande V.

AU - Jablonski, Kathleen

AU - Myatt, Leslie

AU - Roberts, James M.

AU - Tita, Alan T.N.

AU - Leveno, Kenneth J.

AU - Reddy, Uma M.

AU - Varner, Michael W.

AU - Thorp, John M.

AU - Mercer, Brian M.

AU - Peaceman, Alan M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall W.

AU - Samuels, Philip

AU - Sciscione, Anthony

AU - Tolosa, Jorge E.

AU - Saade, George

AU - Sorokin, Yoram

N1 - Funding Information: The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD34208, HD27869, HD40485, HD40560, HD40544, HD34116, HD40512, HD21410, HD40545, HD40500, HD27915, HD34136, HD27860, HD53118, HD53097, HD27917, and HD36801); the National Heart, Lung, and Blood Institute; and the National Center for Research Resources (M01 RR00080, UL1 RR024153, and UL1 RR024989). Comments and views of the authors do not necessarily represent the views of the NIH. Publisher Copyright: © 2019 by Thieme Medical Publishers, Inc.

PY - 2019

Y1 - 2019

N2 - Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

AB - Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

KW - family history

KW - inheritance

KW - ischemic placental disease

KW - placental abruption

KW - preeclampsia

KW - small for gestational age infant

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U2 - 10.1055/s-0038-1672177

DO - 10.1055/s-0038-1672177

M3 - Article

C2 - 30282103

AN - SCOPUS:85065330688

VL - 36

SP - 624

EP - 631

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 6

ER -

Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

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