Risk of Parkinson's disease dementia related to level I MDS PD-MCI

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. Methods: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. Results: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. Conclusions: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalMovement Disorders
Volume34
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • Parkinson's disease
  • dementia
  • mild cognitive impairment
  • neuropsychological tests
  • survival analysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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