Risk of Parkinson's disease dementia related to level I MDS PD-MCI

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”

doi:10.1002/mds.27617

Risk of Parkinson's disease dementia related to level I MDS PD-MCI

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. Methods: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. Results: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. Conclusions: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.

Original language	English (US)
Pages (from-to)	430-435
Number of pages	6
Journal	Movement Disorders
Volume	34
Issue number	3
DOIs	https://doi.org/10.1002/mds.27617
State	Published - Mar 2019

Funding

C. Dalrymple-Alford reports grants from Brain Research New Zealand-Rangahau Roro Aotearoa, Neurological Foundation of New Zealand, Canterbury Medical Research Foundation (NZ), Health Research Council of New Zealand, and Freemasons of New Zealand. Connie Marras reports funding from the Canadian Institutes of Health Research and the Michael J. Fox Foundation. Charles H. Adler reports grants from the NINDS, Arizona Biomedical Research Commission, and Michael J. Fox Foundation. Jennifer G. Goldman reports grants from NIH and the Michael J. Fox Foundation. Alexander I. Tröster reports grants from the Michael J. Fox Foundation during the conduct of the study. Irene Litvan reports grants from the Michael J. Fox Foundation during the conduct of the study. Gert J. Geurtsen reports grants from the Michael J. Fox Foundation and Dutch Parkinson’s Disease Foundation during the conduct of the study. Jeroen Hoogland, Judith A. Boel, Rob M.A. de Bie, Ronald B. Geskus, Ben A. Schmand, Daniel Weintraub, Carme Jun-gué, Kenn F. Pedersen, Brit Mollenhauer, and David J. Burn report no conflicts of interest related to the research in this report. Funding agencies: This study was funded by the Michael J. Fox Foundation and the Dutch Parkinson’s Disease Foundation. agencies: This study was funded by the Michael J. Fox Foundation and the Dutch Parkinson's Disease Foundation.

Keywords

Parkinson's disease
dementia
mild cognitive impairment
neuropsychological tests
survival analysis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.27617

Cite this

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title = "Risk of Parkinson's disease dementia related to level I MDS PD-MCI",

abstract = "Background: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. Methods: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. Results: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. Conclusions: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.",

keywords = "Parkinson's disease, dementia, mild cognitive impairment, neuropsychological tests, survival analysis",

author = "{on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”} and Jeroen Hoogland and Boel, {Judith A.} and {de Bie}, {Rob M.A.} and Schmand, {Ben A.} and Geskus, {Ronald B.} and Dalrymple-Alford, {John C.} and Connie Marras and Adler, {Charles H.} and Daniel Weintraub and Carmen Junque and Pedersen, {Kenn F.} and Brit Mollenhauer and Goldman, {Jennifer G} and Tr{\"o}ster, {Alexander I.} and Burn, {David J.} and Irene Litvan and Geurtsen, {Gert J.}",

note = "Publisher Copyright: {\textcopyright} 2019 International Parkinson and Movement Disorder Society",

year = "2019",

month = mar,

doi = "10.1002/mds.27617",

language = "English (US)",

volume = "34",

pages = "430--435",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley & Sons Inc.",

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T1 - Risk of Parkinson's disease dementia related to level I MDS PD-MCI

AU - on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”

AU - Hoogland, Jeroen

AU - Boel, Judith A.

AU - de Bie, Rob M.A.

AU - Schmand, Ben A.

AU - Geskus, Ronald B.

AU - Dalrymple-Alford, John C.

AU - Marras, Connie

AU - Adler, Charles H.

AU - Weintraub, Daniel

AU - Junque, Carmen

AU - Pedersen, Kenn F.

AU - Mollenhauer, Brit

AU - Goldman, Jennifer G

AU - Tröster, Alexander I.

AU - Burn, David J.

AU - Litvan, Irene

AU - Geurtsen, Gert J.

PY - 2019/3

Y1 - 2019/3

N2 - Background: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. Methods: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. Results: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. Conclusions: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.

AB - Background: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria. Methods: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia. Results: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia. Conclusions: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria.

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KW - dementia

KW - mild cognitive impairment

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KW - survival analysis

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Risk of Parkinson's disease dementia related to level I MDS PD-MCI

Abstract

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Keywords

ASJC Scopus subject areas

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