Abstract
There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn's disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Study results could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-204 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 21 2012 |
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Keywords
- Colectomy
- Crohn's disease
- Post-operative complications
- Ulcerative colitis
ASJC Scopus subject areas
- Gastroenterology
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Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease. / Ali, Tauseef; Yun, Laura; Rubin, David T.
In: World Journal of Gastroenterology, Vol. 18, No. 3, 21.01.2012, p. 197-204.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease
AU - Ali, Tauseef
AU - Yun, Laura
AU - Rubin, David T.
PY - 2012/1/21
Y1 - 2012/1/21
N2 - There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn's disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Study results could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed.
AB - There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn's disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Study results could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed.
KW - Colectomy
KW - Crohn's disease
KW - Post-operative complications
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=84856988917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856988917&partnerID=8YFLogxK
U2 - 10.3748/wjg.v18.i3.197
DO - 10.3748/wjg.v18.i3.197
M3 - Review article
VL - 18
SP - 197
EP - 204
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 3
ER -