Risk of recurrent seizures after a primary human herpesvirus 6-induced febrile seizure

Sandra H. Jee, Christine E. Long, Kenneth C. Schnabel, Neeru Sehgal, Leon G. Epstein*, Caroline Breese Hall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective. To test the hypothesis that children experiencing first febrile seizures caused by human herpesvirus 6 (HHV-6) have an increased risk for recurrent seizures when compared with children experiencing first febrile seizures attributed to other illnesses. Design and participants. Descriptive prospective study of 36 HHV-6 culture-positive children and a matched subgroup of 86 HHV-6 culture-negative children, all of whom had their first febrile seizures evaluated in a tertiary care emergency department and were followed for at least 12 months, with an average follow-up of 35.7 months. Primary outcome measure. The recurrence of seizures among HHV-6 culture- positive and HHV-6 culture-negative children with no known previous neurologic deficits. Results. A decreased incidence of recurrent seizures occurred in children whose first febrile seizures were caused by HHV-6. Twenty percent of HHV-6 culture-positive children and 40% of HHV-6 culture- negative children (P < 0.038) experienced a recurrent seizure within 1 year of their first febrile seizure. The mean time to recurrence within 12 months was 8.6 months for children with HHV-6 infection and 3.8 months (P < 0.001) for children without HHV-6 infection. Most recurrent seizures occurred within 12 months of a first febrile seizure for both HHV-6-positive and HHV-6- negative children (88 and 91%). Conclusions. Children who had their first febrile seizures caused by primary HHV-6 infection did not demonstrate an increased risk for recurrent seizures when compared with children whose first febrile seizures were from other etiologies.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalPediatric Infectious Disease Journal
Volume17
Issue number1
DOIs
StatePublished - Jan 1998

Keywords

  • Exanthem subitum
  • Febrile seizures
  • Human herpesvirus 6
  • Roseola

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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