Risk of urethral stricture recurrence increases over time after urethroplasty

Justin S. Han*, Joceline Liu, Matthias Dominikus Hofer, Amanda Fuchs, Amanda Chi, Daniel Stein, Elodi Dielubanza, Nathaniel Ballek, Chris M. Gonzalez

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Objective: To report a single institutional experience with urethroplasty outcomes and success rates at long-term follow up. Methods: A retrospective review was carried out of all urethroplasties performed by a single surgeon from 2000 to 2010. A total of 347 patients underwent urethroplasty during this time period, of which 227 had minimum 1-year follow-up data available. Demographic, clinical, pathological and outcome data were reviewed. Recurrence was defined by patient reported urinary symptoms or need for subsequent intervention. Statistical analyses were carried out using SPSS statistical software. Results: A total of 26% of all patients had a recurrence at a mean follow up of 62months (range 13-147months). The recurrence rate after anastomotic urethroplasty was 18%, as compared with 31% after substitution urethroplasty. Mean time to recurrence was 34months (range 5-87). On univariate analysis, use of abdominal skin graft, history of prior urethroplasty, lichen sclerosus and length of follow up were statistically significant predictors of recurrence. On multivariate analysis, only history of prior urethroplasty and length of follow-up time exceeding 48months were statistically significant predictors of recurrence. Conclusions: Urethroplasty for urethral stricture is the most durable treatment modality, regardless of surgical approach. However, there is an ongoing risk of recurrence with the passage of time. Patients should be counseled appropriately on the potential for late recurrence of stricture disease after urethroplasty.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalInternational Journal of Urology
Volume22
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Micturition
  • Prognosis
  • Recurrence
  • Treatment outcome
  • Urethral stricture

ASJC Scopus subject areas

  • Urology

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    Han, J. S., Liu, J., Hofer, M. D., Fuchs, A., Chi, A., Stein, D., Dielubanza, E., Ballek, N., & Gonzalez, C. M. (2015). Risk of urethral stricture recurrence increases over time after urethroplasty. International Journal of Urology, 22(7), 695-699. https://doi.org/10.1111/iju.12781