RNA-binding proteins in neurological diseases

Hua Lin Zhou, Marie Mangelsdorf, Jiang Hong Liu, Li Zhu, Jane Y. Wu

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.

Original languageEnglish (US)
Pages (from-to)432-444
Number of pages13
JournalScience China Life Sciences
Volume57
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • RNA-binding proteins
  • neurological diseases
  • post-transcriptional regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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