Abstract
Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 432-444 |
| Number of pages | 13 |
| Journal | Science China Life Sciences |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2014 |
Funding
Zhou HuaLin is supported by National Basic Research Program of China (2013CB917803) and research fund for the State Key Laboratory of Cognitive Neuroscience and Learning from Institute of Biophysics, Chinese Academy of Sciences (7Y1SNY7007). Marie Mangelsdorf is supported by the Ross Maclean Senior Research Fellowship and the Peter Goodenough Bequest. Zhu Li and Liu JiangHong are supported by grants from the National Major Basic Research Program of China (2010CB529603) and the National Natural Science Foundation of China (91132710, 31200561). Jane Y. Wu is supported by the US National Institutes of Health.
Keywords
- RNA-binding proteins
- neurological diseases
- post-transcriptional regulation
ASJC Scopus subject areas
- General Environmental Science
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences
