RNA dependent DNA polymerase activity of RNA tumor virus. VI. Processive mode of action of avian myeloblastosis virus polymerase

Purified avian myeloblastosis virus (AMV) polymerase consisting of α,β subunits has been shown to act processively in catalyzing DNA synthesis primed with 34S AMV RNA.oligo(dT), poly(A).poly(dT), and poly(I).poly(dC). DNA transcripts prepared with 34S AMV RNA.oligo(dT)₁₄ and AMV polymerase (αβ) have been shown to have a molecular weight of 1.05 x 10⁶, or approximately one third the size of the 34S RNA genome. Polymerase subunit α acts nonprocessively with the above templates.