RNA interference directs innate immunity against viruses in adult Drosophila

Xiao Hong Wang, Roghiyh Aliyari, Wan Xiang Li, Hong Wei Li, Kevin Kim, Richard Carthew, Peter Atkinson, Shou Wei Ding*

*Corresponding author for this work

Research output: Contribution to journalArticle

500 Scopus citations

Abstract

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (lmd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

Original languageEnglish (US)
Pages (from-to)452-454
Number of pages3
JournalScience
Volume312
Issue number5772
DOIs
StatePublished - Apr 21 2006

ASJC Scopus subject areas

  • General

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    Wang, X. H., Aliyari, R., Li, W. X., Li, H. W., Kim, K., Carthew, R., Atkinson, P., & Ding, S. W. (2006). RNA interference directs innate immunity against viruses in adult Drosophila. Science, 312(5772), 452-454. https://doi.org/10.1126/science.1125694