RNA interference directs innate immunity against viruses in adult Drosophila

Xiao Hong Wang; Roghiyh Aliyari; Wan Xiang Li; Hong Wei Li; Kevin Kim; Richard Carthew; Peter Atkinson; Shou Wei Ding

doi:10.1126/science.1125694

RNA interference directs innate immunity against viruses in adult Drosophila

Xiao Hong Wang, Roghiyh Aliyari, Wan Xiang Li, Hong Wei Li, Kevin Kim, Richard Carthew, Peter Atkinson, Shou Wei Ding^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

615 Scopus citations

Abstract

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (lmd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

Original language	English (US)
Pages (from-to)	452-454
Number of pages	3
Journal	Science
Volume	312
Issue number	5772
DOIs	https://doi.org/10.1126/science.1125694
State	Published - Apr 21 2006

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AU - Kim, Kevin

AU - Carthew, Richard

AU - Atkinson, Peter

AU - Ding, Shou Wei

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N2 - Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (lmd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

AB - Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (lmd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.

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RNA interference directs innate immunity against viruses in adult Drosophila

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