RNA interference

The fragile X syndrome connection

Richard W Carthew*

*Corresponding author for this work

Research output: Contribution to journalShort survey

27 Citations (Scopus)

Abstract

Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.

Original languageEnglish (US)
JournalCurrent Biology
Volume12
Issue number24
DOIs
StatePublished - Dec 23 2002

Fingerprint

Fragile X Mental Retardation Protein
Fragile X Syndrome
Protein Biosynthesis
RNA Interference
RNA interference
translation (genetics)
protein synthesis
RNA
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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title = "RNA interference: The fragile X syndrome connection",
abstract = "Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.",
author = "Carthew, {Richard W}",
year = "2002",
month = "12",
day = "23",
doi = "10.1016/S0960-9822(02)01352-0",
language = "English (US)",
volume = "12",
journal = "Current Biology",
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publisher = "Cell Press",
number = "24",

}

RNA interference : The fragile X syndrome connection. / Carthew, Richard W.

In: Current Biology, Vol. 12, No. 24, 23.12.2002.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - RNA interference

T2 - The fragile X syndrome connection

AU - Carthew, Richard W

PY - 2002/12/23

Y1 - 2002/12/23

N2 - Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.

AB - Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.

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U2 - 10.1016/S0960-9822(02)01352-0

DO - 10.1016/S0960-9822(02)01352-0

M3 - Short survey

VL - 12

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 24

ER -