RNA recognition by the MS2 phage coat protein

Hans E. Johansson*, Lars Liljas, Olke C. Uhlenbeck

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations


The interaction of MS2 coat protein and its translational operator hairpin is a very well-characterized RNA-protein complex. The recent high-resolution cocrystal structure successfully explains many biochemical experiments measuring the affinity of the protein-RNA interaction for mutant proteins and chemically modified RNAs. However, an analysis of a tight binding variant of the RNA suggests that the conformation of the free RNA is also an important determinant of the affinity.

Original languageEnglish (US)
Pages (from-to)176-185
Number of pages10
JournalSeminars in Virology
Issue number3
StatePublished - Jan 1 1997


  • Bacteriophage MS2 RNA
  • RNA-protein interaction
  • Translational repression

ASJC Scopus subject areas

  • Immunology
  • Virology

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