RNA systems biology: Uniting functional discoveries and structural tools to understand global roles of RNAs

Eric J. Strobel, Kyle E. Watters, David Loughrey, Julius B. Lucks*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

RNAs assume sophisticated structures that are active in myriad cellular processes. In this review, we highlight newly identified ribozymes, riboswitches, and small RNAs, some of which control the function of cellular metabolic and gene expression networks. We then examine recent developments in genome-wide RNA structure probing technologies that are yielding new insights into the structural landscape of the transcriptome. Finally, we discuss how these RNA 'structomic' methods can address emerging questions in RNA systems biology, from the mechanisms behind long non-coding RNAs to new bases for human diseases.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalCurrent Opinion in Biotechnology
Volume39
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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