Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L)

Jing Zhang, Lei Fang, Xuguo Zhu, Yiting Qiao, Mei Yu, Lu Wang, Yuan Chen, Wu Yin, Zi Chun Hua*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Ro52/SSA is an autoantigen that presents in patients with SS (Sjögren's syndrome) and SLE (systemic lupus erythematosus). It increases cell death and redistributes itself to apoptotic blebs, but its pro-apoptotic function has not been completely identified. Overexpression of Ro52/SSA promoted cell apoptosis induced by DR (death receptor) in caspase-8-dependent manner. Ro52/SSA expression down-regulated c-FLIP(L) [cellular (Fas-associated death domain)-like interleukin 1β-converting enzyme-inhibitory protein long form] expression, and Ro52/SSA siRNAs (small interfering RNAs) increased c-FLIP(L) production, indicating that Ro52/SSA plays a role in c-FLIP(L) regulation. Ro52/SSA negatively regulated c-FLIP(L) transcriptional level probably by suppressing NF-κB (nuclear factor kB) signalling. The data suggest that Ro52/SSA is involved in DR-mediated apoptosis by regulating c-FLIP(L).

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalCell Biology International
Volume36
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • Caspase-8
  • Cellular (Fas-associated death domain)-like interleukin 1β-converting enzyme-inhibitory protein (c-FLIP)
  • Nuclear factor κβ (NF-κβ)
  • Ro52/SSA
  • Tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL)

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Zhang, J., Fang, L., Zhu, X., Qiao, Y., Yu, M., Wang, L., Chen, Y., Yin, W., & Hua, Z. C. (2012). Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L). Cell Biology International, 36(5), 463-468. https://doi.org/10.1042/CBI20110322