Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

Denana U. Miodragovic̈, Jeremy A. Quentzel, Josh W. Kurutz, Charlotte L. Stern, Richard W. Ahn, Irawati Kandela, Andrew Mazar, Thomas V. O'Halloran*

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The PtII-AsIII bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.

Original languageEnglish (US)
Pages (from-to)10749-10752
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number41
DOIs
StatePublished - Oct 4 2013

Keywords

  • X-ray diffraction
  • antitumor agents
  • arsenic
  • drug design
  • platinum

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes'. Together they form a unique fingerprint.

  • Cite this

    Miodragovic̈, D. U., Quentzel, J. A., Kurutz, J. W., Stern, C. L., Ahn, R. W., Kandela, I., Mazar, A., & O'Halloran, T. V. (2013). Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes. Angewandte Chemie - International Edition, 52(41), 10749-10752. https://doi.org/10.1002/anie.201303251