Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas

Megan E. Gumina; Madeline J. Hooper; Xiaolong A. Zhou; Sergei B. Koralov

doi:10.1016/j.jid.2023.10.023

Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas

Megan E. Gumina, Madeline J. Hooper, Xiaolong A. Zhou^*, Sergei B. Koralov^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of the exposure is still unknown.

Original language	English (US)
Pages (from-to)	755-763
Number of pages	9
Journal	Journal of Investigative Dermatology
Volume	144
Issue number	4
DOIs	https://doi.org/10.1016/j.jid.2023.10.023
State	Published - Apr 2024

Funding

Work in SBK’s laboratory was supported by the National Institutes of Health (R01CA271245), the LEO Foundation Grant (LF-OC-20-000351), NYU Cancer Center Pilot grant (P30CA016087), and the Judith and Stewart Colton Center for Autoimmunity Pilot grant. Work in XAZ’s laboratory was supported by career development awards from the Dermatology Foundation and Lymphoma Research Foundation, a Cutaneous Lymphoma Foundation Catalyst Research Grant, and institutional grants from the American Cancer Society and National Institutes of Health (KL2TR001424). SBK is the guarantor for this work. This work was presented at the 69th annual Montagna Symposium on the Biology of Skin, “Microbes, Autoimmunity & Cancer,” held October 20–24, 2022. SBK’s laboratory has received funding from Micreos, Dracen Pharmaceuticals, Kymera Therapeutics, and Bristol Myers Squibb.

Keywords

Cutaneous T-Cell Lymphoma
Immunology
Microbiome

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

Access to Document

10.1016/j.jid.2023.10.023

Cite this

@article{fe298c43918443aba75046207559fdf0,

title = "Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas",

abstract = "Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of the exposure is still unknown.",

keywords = "Cutaneous T-Cell Lymphoma, Immunology, Microbiome",

author = "Gumina, {Megan E.} and Hooper, {Madeline J.} and Zhou, {Xiaolong A.} and Koralov, {Sergei B.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2024",

month = apr,

doi = "10.1016/j.jid.2023.10.023",

language = "English (US)",

volume = "144",

pages = "755--763",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas

AU - Gumina, Megan E.

AU - Hooper, Madeline J.

AU - Zhou, Xiaolong A.

AU - Koralov, Sergei B.

PY - 2024/4

Y1 - 2024/4

N2 - Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of the exposure is still unknown.

AB - Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of the exposure is still unknown.

KW - Cutaneous T-Cell Lymphoma

KW - Immunology

KW - Microbiome

UR - http://www.scopus.com/inward/record.url?scp=85183426744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85183426744&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2023.10.023

DO - 10.1016/j.jid.2023.10.023

M3 - Review article

C2 - 38149950

AN - SCOPUS:85183426744

SN - 0022-202X

VL - 144

SP - 755

EP - 763

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 4

ER -

Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this