Role of Bcl-2 family members in anoxia induced cell death

Emelyn H. Shroff, Colleen Snyder, Navdeep Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

35 Citations (Scopus)

Abstract

Anoxia, the condition of oxygen deprivation, induces apoptosis via the intrinsic apoptotic pathway. Cells deficient in both Bax and Bak do not undergo cell death during anoxia. However, the underlying mechanism of anoxia induced cell death is not well defined. Here we report our latest findings of two critical events that are required to induce cell death during anoxia. First, a key member of the Bcl-2 family of pro-survival proteins, Mcl-1, undergoes proteasomal-dependent degradation. The loss of Mcl-1 protein is independent of Bax or Bak indicating this is an early event in the apoptotic cascade. Second, cells inhibit the mitochondrial electron transport chain to negate the pro-survival function of Bcl-2/Bcl-XL. These observations indicate that loss of pro-survival function is necessary for anoxia induced cell death.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalCell Cycle
Volume6
Issue number7
DOIs
StatePublished - Apr 1 2007

Fingerprint

Cell Death
Electron Transport
Proteins
Hypoxia
Apoptosis
Oxygen

Keywords

  • Anoxia
  • BH3-only proteins
  • Hypoxia

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Shroff, Emelyn H. ; Snyder, Colleen ; Chandel, Navdeep. / Role of Bcl-2 family members in anoxia induced cell death. In: Cell Cycle. 2007 ; Vol. 6, No. 7. pp. 807-809.
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Role of Bcl-2 family members in anoxia induced cell death. / Shroff, Emelyn H.; Snyder, Colleen; Chandel, Navdeep.

In: Cell Cycle, Vol. 6, No. 7, 01.04.2007, p. 807-809.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Role of Bcl-2 family members in anoxia induced cell death

AU - Shroff, Emelyn H.

AU - Snyder, Colleen

AU - Chandel, Navdeep

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N2 - Anoxia, the condition of oxygen deprivation, induces apoptosis via the intrinsic apoptotic pathway. Cells deficient in both Bax and Bak do not undergo cell death during anoxia. However, the underlying mechanism of anoxia induced cell death is not well defined. Here we report our latest findings of two critical events that are required to induce cell death during anoxia. First, a key member of the Bcl-2 family of pro-survival proteins, Mcl-1, undergoes proteasomal-dependent degradation. The loss of Mcl-1 protein is independent of Bax or Bak indicating this is an early event in the apoptotic cascade. Second, cells inhibit the mitochondrial electron transport chain to negate the pro-survival function of Bcl-2/Bcl-XL. These observations indicate that loss of pro-survival function is necessary for anoxia induced cell death.

AB - Anoxia, the condition of oxygen deprivation, induces apoptosis via the intrinsic apoptotic pathway. Cells deficient in both Bax and Bak do not undergo cell death during anoxia. However, the underlying mechanism of anoxia induced cell death is not well defined. Here we report our latest findings of two critical events that are required to induce cell death during anoxia. First, a key member of the Bcl-2 family of pro-survival proteins, Mcl-1, undergoes proteasomal-dependent degradation. The loss of Mcl-1 protein is independent of Bax or Bak indicating this is an early event in the apoptotic cascade. Second, cells inhibit the mitochondrial electron transport chain to negate the pro-survival function of Bcl-2/Bcl-XL. These observations indicate that loss of pro-survival function is necessary for anoxia induced cell death.

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