Abstract
Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 474-483 |
| Number of pages | 10 |
| Journal | IEEE Transactions on Biomedical Engineering |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 23 2001 |
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Keywords
- Endothelial cell migration
- Intimal hyperplasia
- Vortex flow
ASJC Scopus subject areas
- Biomedical Engineering
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Role of blood shear stress in the regulation of vascular smooth muscle cell migration. / Liu, Shu Qian; Goldman, Jeremy.
In: IEEE Transactions on Biomedical Engineering, Vol. 48, No. 4, 23.04.2001, p. 474-483.Research output: Contribution to journal › Article
TY - JOUR
T1 - Role of blood shear stress in the regulation of vascular smooth muscle cell migration
AU - Liu, Shu Qian
AU - Goldman, Jeremy
PY - 2001/4/23
Y1 - 2001/4/23
N2 - Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.
AB - Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.
KW - Endothelial cell migration
KW - Intimal hyperplasia
KW - Vortex flow
UR - http://www.scopus.com/inward/record.url?scp=0035068721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035068721&partnerID=8YFLogxK
U2 - 10.1109/10.915714
DO - 10.1109/10.915714
M3 - Article
C2 - 11322535
AN - SCOPUS:0035068721
VL - 48
SP - 474
EP - 483
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
SN - 0018-9294
IS - 4
ER -