Role of blood shear stress in the regulation of vascular smooth muscle cell migration

Shu Qian Liu*, Jeremy Goldman

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.

Original languageEnglish (US)
Pages (from-to)474-483
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume48
Issue number4
DOIs
StatePublished - Apr 23 2001

Fingerprint

Muscle
Shear stress
Blood
Cells
Tissue
Laminar flow
Vortex flow
Blood vessels
Surgery
Rats

Keywords

  • Endothelial cell migration
  • Intimal hyperplasia
  • Vortex flow

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

@article{e2fbb636b37b462f91abb15088a1eb57,
title = "Role of blood shear stress in the regulation of vascular smooth muscle cell migration",
abstract = "Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.",
keywords = "Endothelial cell migration, Intimal hyperplasia, Vortex flow",
author = "Liu, {Shu Qian} and Jeremy Goldman",
year = "2001",
month = "4",
day = "23",
doi = "10.1109/10.915714",
language = "English (US)",
volume = "48",
pages = "474--483",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "4",

}

Role of blood shear stress in the regulation of vascular smooth muscle cell migration. / Liu, Shu Qian; Goldman, Jeremy.

In: IEEE Transactions on Biomedical Engineering, Vol. 48, No. 4, 23.04.2001, p. 474-483.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of blood shear stress in the regulation of vascular smooth muscle cell migration

AU - Liu, Shu Qian

AU - Goldman, Jeremy

PY - 2001/4/23

Y1 - 2001/4/23

N2 - Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.

AB - Smooth muscle cell (SMC) migration from the media to the intima of blood vessels contributes to neointimal formation and atherogenesis. Here, we demonstrate how blood shear stress regulates vascular SMC migration in the encapsulating tissue of a micro-cylinder implanted in the center of the rat vena cava with the micro-cylinder perpendicular to blood flow. In this model, the micro-cylinder was exposed to a laminar flow with a known shear stress field in the leading region and a vortex flow in the trailing region. After surgery, the micro-cylinder was encapsulated by a thrombus-like tissue within one day, followed by SMC migration from the vena cava to the encapsulating tissue from day 3 to 20. SMC migration was time-dependent with a peak migration speed at day 5. At each given time (excluding day 1), blood shear stress exerts an inhibitory effect on SMC migration with significantly suppressed SMC migration in the laminar flow region than in the stagnation, separation, and vortex flow regions. SMCs were relatively parallel to the shear stress direction in high shear stress regions, whereas perpendicular to the shear stress direction in low shear stress regions. These results suggest that blood shear stress plays a role in regulating SMC migration and orientation in this model.

KW - Endothelial cell migration

KW - Intimal hyperplasia

KW - Vortex flow

UR - http://www.scopus.com/inward/record.url?scp=0035068721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035068721&partnerID=8YFLogxK

U2 - 10.1109/10.915714

DO - 10.1109/10.915714

M3 - Article

C2 - 11322535

AN - SCOPUS:0035068721

VL - 48

SP - 474

EP - 483

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

IS - 4

ER -