Role of CBP/P300 in nuclear receptor signalling

D. Chakravarti; V. J. LaMorte; M. C. Nelson; T. Nakajima; I. G. Schulman; H. Juguilon; M. Montminy; R. M. Evans

doi:10.1038/383099a0

Role of CBP/P300 in nuclear receptor signalling

D. Chakravarti, V. J. LaMorte, M. C. Nelson, T. Nakajima, I. G. Schulman, H. Juguilon, M. Montminy, R. M. Evans^*

^*Corresponding author for this work

Obstetrics and Gynecology

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Abstract

THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins. An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation. Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.

Original language	English (US)
Pages (from-to)	99-103
Number of pages	5
Journal	Nature
Volume	383
Issue number	6595
DOIs	https://doi.org/10.1038/383099a0
State	Published - Jan 1 1996

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title = "Role of CBP/P300 in nuclear receptor signalling",

abstract = "THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins. An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation. Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.",

author = "D. Chakravarti and LaMorte, {V. J.} and Nelson, {M. C.} and T. Nakajima and Schulman, {I. G.} and H. Juguilon and M. Montminy and Evans, {R. M.}",

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T1 - Role of CBP/P300 in nuclear receptor signalling

AU - Chakravarti, D.

AU - LaMorte, V. J.

AU - Nelson, M. C.

AU - Nakajima, T.

AU - Schulman, I. G.

AU - Juguilon, H.

AU - Montminy, M.

AU - Evans, R. M.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins. An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation. Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.

AB - THE nuclear receptor superfamily includes receptors for steroids, retinoids, thyroid hormone and vitamin D, as well as many related proteins. An important feature of the action of the lipophilic hormones and vitamins is that the maintenance of homeostatic function requires both intrinsic positive and negative regulation. Here we provide in vitro and in vivo evidence that identifies the CREB-binding protein (CBP) and its homologue P300 (refs 6, 7) as cofactors mediating nuclear-receptor-activated gene transcription. The role of CBP/P300 in the transcriptional response to cyclic AMP, phorbol esters, serum, the lipophilic hormones and as the target of the E1A oncoprotein suggests they may serve as integrators of extracellular and intracellular signalling pathways.

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Role of CBP/P300 in nuclear receptor signalling

Abstract

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