Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.
|Original language||English (US)|
|Number of pages||5|
|Journal||Current Opinion in Immunology|
|State||Published - Dec 1993|
ASJC Scopus subject areas
- Immunology and Allergy