Role of CD40-CD40-ligand interaction in Ig-isotype switching

Ramsay Fuleihan; Narayanaswamy Ramesh; Raif S. Geha

doi:10.1016/0952-7915(93)90113-7

Role of CD40-CD40-ligand interaction in Ig-isotype switching

Ramsay Fuleihan^*, Narayanaswamy Ramesh, Raif S. Geha

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

Original language	English (US)
Pages (from-to)	963-967
Number of pages	5
Journal	Current Opinion in Immunology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0952-7915(93)90113-7
State	Published - Dec 1993

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(93)90113-7

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title = "Role of CD40-CD40-ligand interaction in Ig-isotype switching",

abstract = "Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.",

author = "Ramsay Fuleihan and Narayanaswamy Ramesh and Geha, {Raif S.}",

note = "Funding Information: This work was supported by USPHS grants RR-02172, AI31136, AI31541 to RSG, by a grant from the March of Dimes 6-0760 (RSG) and by grants from Caremark, Critical Care of America and Home Nutritional Services. RF is suppotted by grants from the Immunodeficiency Foundation (Cutter Award) and the Lucille P Markey trust.",

year = "1993",

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doi = "10.1016/0952-7915(93)90113-7",

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AU - Fuleihan, Ramsay

AU - Ramesh, Narayanaswamy

AU - Geha, Raif S.

N1 - Funding Information: This work was supported by USPHS grants RR-02172, AI31136, AI31541 to RSG, by a grant from the March of Dimes 6-0760 (RSG) and by grants from Caremark, Critical Care of America and Home Nutritional Services. RF is suppotted by grants from the Immunodeficiency Foundation (Cutter Award) and the Lucille P Markey trust.

PY - 1993/12

Y1 - 1993/12

N2 - Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

AB - Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

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Role of CD40-CD40-ligand interaction in Ig-isotype switching

Abstract

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