Role of CD40-CD40-ligand interaction in Ig-isotype switching

Ramsay Fuleihan*, Narayanaswamy Ramesh, Raif S. Geha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.

Original languageEnglish (US)
Pages (from-to)963-967
Number of pages5
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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