Role of Citrate, Lactate, Pyruvate, and Fatty Acids in Albumin-Induced Bone Resorption

Paula H. Stern; Robert H. Earhart

doi:10.3181/00379727-139-36280

Role of Citrate, Lactate, Pyruvate, and Fatty Acids in Albumin-Induced Bone Resorption

Paula H. Stern, Robert H. Earhart

Pharmacology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Several substances known to be bound to serum albumin were tested for bone resorbing activity. Citrate, lactate, and pyruvate were ineffective in the concentration range present in albumin. Fatty acids stimulated bone resorption. However, the fatty acid content of several albumins did not correlate well with the bone resorbing activity of these same proteins.

Original language	English (US)
Pages (from-to)	981-984
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	139
Issue number	3
DOIs	https://doi.org/10.3181/00379727-139-36280
State	Published - Mar 1972

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Role of Citrate, Lactate, Pyruvate, and Fatty Acids in Albumin-Induced Bone Resorption",

abstract = "Several substances known to be bound to serum albumin were tested for bone resorbing activity. Citrate, lactate, and pyruvate were ineffective in the concentration range present in albumin. Fatty acids stimulated bone resorption. However, the fatty acid content of several albumins did not correlate well with the bone resorbing activity of these same proteins.",

author = "Stern, {Paula H.} and Earhart, {Robert H.}",

note = "Funding Information: Supported by U.S. Public Health Service Grant AM 11262.",

year = "1972",

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AU - Earhart, Robert H.

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N2 - Several substances known to be bound to serum albumin were tested for bone resorbing activity. Citrate, lactate, and pyruvate were ineffective in the concentration range present in albumin. Fatty acids stimulated bone resorption. However, the fatty acid content of several albumins did not correlate well with the bone resorbing activity of these same proteins.

AB - Several substances known to be bound to serum albumin were tested for bone resorbing activity. Citrate, lactate, and pyruvate were ineffective in the concentration range present in albumin. Fatty acids stimulated bone resorption. However, the fatty acid content of several albumins did not correlate well with the bone resorbing activity of these same proteins.

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Role of Citrate, Lactate, Pyruvate, and Fatty Acids in Albumin-Induced Bone Resorption

Abstract

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