Role of estrogen receptor-β in endometriosis

Serdar E. Bulun*, Diana Monsavais, Mary Ellen Pavone, Matthew Dyson, Qing Xue, Erkut Attar, Hideki Tokunaga, Emily J. Su

*Corresponding author for this work

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e.g., inflammation and growth) and the symptoms (e.g., pain) associated with endometriosis. Abundant quantities of estradiol are available for endometriotic tissue via several mechanisms including local aromatase expression. The question remains, then, what mediates estradiol action. Because estrogen receptor (ER) levels in endometriosis are >100 times higher than those in endometrial tissue, this review focuses on this nuclear receptor. Deficient methylation of the ER promoter results in pathological overexpression of ER in endometriotic stromal cells. High levels of ER suppress ER expression. A severely high ER-βto-ER ratio in endometriotic stromal cells is associated with suppressed progesterone receptor and increased cyclo-oxygenase-2 levels contributing to progesterone resistance and inflammation. ER-βselective estradiol antagonists may serve as novel therapeutics of endometriosis in the future.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalSeminars in reproductive medicine
Volume30
Issue number1
DOIs
StatePublished - 2012

Keywords

  • DNA methylation
  • ER-β
  • PR
  • epigenetic
  • estrogen
  • nuclear receptor
  • promoter

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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    Bulun, S. E., Monsavais, D., Pavone, M. E., Dyson, M., Xue, Q., Attar, E., Tokunaga, H., & Su, E. J. (2012). Role of estrogen receptor-β in endometriosis. Seminars in reproductive medicine, 30(1), 39-45. https://doi.org/10.1055/s-0031-1299596