Role of group 1 CD1-restricted T cells in infectious disease

Sarah Siddiqui, Lavanya Visvabharathy, Chyung Ru Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases. In this review, we summarize current knowledge and recent discoveries on the development of group 1 CD1-restricted T cells and their function in different infection models. In particular, we focus on (1) newly identified microbial and self-lipid antigens, (2) kinetics, phenotype, and unique properties of group 1 CD1-restricted T cells during infection, and (3) the similarities of group 1 CD1-restricted T cells to the closely related group 2 CD1-restricted T cells.

Original languageEnglish (US)
Article number337
JournalFrontiers in immunology
Issue numberJUN
StatePublished - 2015


  • Animal models
  • Antigen presentation
  • CD1
  • Mycobacterium tuberculosis
  • NKT cells
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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