Role of Group 1 CD1–Restricted T Cells in Host Defense and Inflammatory Diseases

Eva Morgun, Liang Cao, Chyung Ru Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Group 1 CD1–restricted T cells are members of the unconventional T cell family that recognize lipid antigens presented by CD1a, CD1b, and CD1c molecules. Although they developmentally mirror invariant natural killer T cells, they have diverse antigen specificity and functional capacity, with both anti-microbial and autoreactive targets. The role of group 1 CD1–restricted T cells has been best established in Mycobacterium tuberculosis (Mtb) infection in which a wide variety of lipid antigens have been identified and their ability to confer protection against Mtb infection in a CD1 transgenic mouse model has been shown. Group 1 CD1–restricted T cells have also been implicated in other infections, inflammatory conditions, and malignancies. In particular, autoreactive group 1 CD1–restricted T cells have been shown to play a role in several skin inflammatory conditions. The prevalence of group 1 CD1 autoreactive T cells in healthy individuals suggests the presence of regulatory mechanisms to suppress autoreactivity in homeostasis. The more recent use of group 1 CD1 tetramers and mouse models has allowed for better characterization of their phenotype, functional capacity, and underlying mechanisms of antigen-specific and autoreactive activation. These discoveries may pave the way for the development of novel vaccines and immunotherapies that target group 1 CD1–restricted T cells.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalCritical reviews in immunology
Volume41
Issue number4
DOIs
StatePublished - 2021

Keywords

  • CD1
  • T cells
  • animamodels
  • antigen presentation
  • autoimmunity
  • infection
  • inflammation
  • tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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