Role of hepatic metastatic lesion size on inter-reader reproducibility of CT-based radiomics features

Linda C. Kelahan, Donald Kim, Moataz Soliman, Ryan J. Avery, Hatice Savas, Rishi Agrawal, Michael Magnetta, Benjamin P. Liu, Yuri S. Velichko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives: To evaluate the effect of hepatic metastatic lesion size on inter-reader reproducibility of CT-based 2D radiomics imaging features. Methods: Computerized tomography (CT) scans of 59 liver metastases from 34 patients with colorectal cancer were evaluated. Image segmentation was performed manually by three readers blinded to each other’s results. For each radiomics feature, we created two datasets by sorting measurements according to size, i.e., (i) from the smallest to the largest lesion and (ii) from the largest to the smallest lesion. The Lin concordance correlation coefficient (CCC) was employed to analyze the reproducibility of radiomics features. In particular, the CCC was computed as a function of a number of elements in the dataset, by gradually adding lesions from each sorted dataset. To evaluate the effect of lesion size, we analyzed the difference between these two functions thus assessing the contribution of small and large lesions into the reproducibility of radiomics features. Results: Inter-reader reproducibility of CT-based 2D radiomics features assessed using Lin’s CCC demonstrates tumor-size dependence. For example, the Lin CCC for GLCM contrast equals 0.88 (95% C.I. 0.84 to 0.92, p < 0.003) and could change by an additional + / − 0.06 depending on the presence of large or small lesions. Conclusions: Groups of “large” and “small” lesions show different inter-reader reproducibility. The inter-reader reproducibility from the mixed group consisting of “large” and “small” lesions depends on the lesion-size distribution and can vary widely. This finding could partially explain variability in reproducibility of radiomics features in the literature. Key Points: • Groups of “large” and “small” lesions show different inter-reader reproducibility. • The inter-reader reproducibility from the mixed group consisting of “large” and “small” lesions depends on the lesion-size distribution.

Original languageEnglish (US)
Pages (from-to)4025-4033
Number of pages9
JournalEuropean Radiology
Volume32
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • Computer tomography
  • Liver metastasis
  • Radiomics
  • Reproducibility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Role of hepatic metastatic lesion size on inter-reader reproducibility of CT-based radiomics features'. Together they form a unique fingerprint.

Cite this