Abstract
PURPOSE OF REVIEW: IL-32 is a recently described proinflammatory cytokine and has been reported to be involved in inflammatory diseases. The purpose of this review is to discuss the role of IL-32 in chronic rhinosinusitis (CRS). RECENT FINDINGS: Two groups have recently reported data regarding the expression of IL-32 in CRS. IL-32 was induced by IFN-γ, TNF-α, dsRNA, and incubation with Th1 cells in primary nasal epithelial cells. IL-32 may be elevated in epithelial cells from patients with CRS without nasal polyps. IL-32 was significantly elevated in whole sinonasal tissue samples of nasal polyps compared with control tissue. IL-32 mRNA expression positively correlated with mRNA for CD3 and macrophage mannose receptor in nasal polyp tissue. Immunohistochemical studies demonstrated localization of IL-32 in epithelium, CD3 and CD68 cells, suggesting that epithelial cells, T cells, and macrophages are the major IL-32-producing cells in CRS. Activation of these cell types may trigger IL-32-related inflammation in CRS. SUMMARY: Elevated levels of IL-32 may play a role in the pathogenesis of CRS through its role as a proinflammatory cytokine and as an endogenous enhancer of pathogen-dependent cytokine production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-18 |
| Number of pages | 6 |
| Journal | Current Opinion in Allergy and Clinical Immunology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2013 |
Keywords
- T cells
- chronic rhinosinusitis
- epithelial cells
- interleukin-32
- macrophages
- nasal polyps
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
