Role of mast cells in allergy

Hirohisa Saito*, Atsushi Kato, Kenji Matsumoto

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Mast cells play a central role in IgE-mediated immediate-type allergic reaction and contribute to the late-phase allergic inflammation by releasing a variety of cytokines and chemokines. These cells also have a substantial effect on tissue remodeling, especially on airway smooth muscle hypertrophy and mucus hypersecretion by releasing proteases and growth factors such as tryptase and amphiregulin. The activation of mast cells in vitro is partially inhibited by the pretreatment with corticosteroid or tacrolimus through inhibition of NF-kappaB and NF-AT, respectively, and is profoundly blocked by the simultaneous treatment of the two drugs. Pharmaceutical development of safer drugs is expected to treat mast cell-mediated allergic disorders.

Original languageEnglish (US)
Pages (from-to)2083-2087
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume67
Issue number11
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Medicine(all)

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