Role of microparticles in the hemostatic dysfunction in acute promyelocytic leukemia

Hau C. Kwaan, Eduardo Magalhães Rego

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Serious bleeding and thrombotic complications are frequent in acute promyelocytic leukemia (APL) and are major causes of morbidity and mortality. Microparticles (MP) have been used to study the risk and pathogenesis of thrombosis in many malignant disorders. To date, from published articles, this approach had not been applied to APL. In this article, the hemostatic dysfunction in this disorder is briefly reviewed. A study design to address this problem using MP is described. MP bearing tissue factor, profibrinolytic factors (tissue plasminogen activator and annexin A2), and the antifibrinolytic factor plasminogen activator inhibitor type 1 were measured using flow cytometry. The cellular origin of the MP was identified by specific cell surface markers. Comparison of the various populations of MP was made between samples collected at the time of diagnosis with those collected at molecular remission. Preliminary data suggest that this approach is feasible.

Original languageEnglish (US)
Pages (from-to)917-924
Number of pages8
JournalSeminars in thrombosis and hemostasis
Volume36
Issue number8
DOIs
StatePublished - Nov 15 2010

Keywords

  • Acute promyelocytic leukemia
  • bleeding
  • microparticles
  • thrombosis
  • tissue factor; annexin A2

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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