Role of Na-K-atpase in the renal reabsorption of sodium in the elasmobranch, squalus acanthias

John P. Hayslett*, Lee M. Jampol, John N. Forrest, Mark Epstein, H. Victor Murdaugh, Jack D. Myers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

1. 1. The relative importance of Na-K-activated ATPase in active bulk transport of Na+ in the elasmobranch kidney was examined. Fractional Na+ excretion was examined before and after the administration of ouabain, associated with over a 60 per cent reduction in enzyme activity, as well as following furosemide and ethacrynic acid. 2. 2. Marked inhibition of Na-K-ATPase with ouabain did not reduce Na+ reabsorption, in contrast to furosemide and ethacrynic acid which increased fractional excretion from 0·22 to 0·69. 3. 3. These data suggest that Na-K-ATPase does not participate in bulk transport of Na+ in the elasmobranch kidney, where the conservation of Na+ is of little importance in osmoregulation.

Original languageEnglish (US)
Pages (from-to)417-422
Number of pages6
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume44
Issue number2
DOIs
StatePublished - Feb 1 1973

Keywords

  • Na-K-ATPase
  • Squalus acanthias
  • ethacrynic acid
  • furosemide
  • renal reabsorption
  • sodium transport

ASJC Scopus subject areas

  • Physiology

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