Role of Neuroinflammation in Neurodegenerative Disorders

Vishwa Mohan, Chandrakanth Reddy Edamakanti, Vyom Sharma

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Neurological disorders are characterized by progressive loss/damage of specific nerve cells due to accumulation of the disease-specific proteins. There is growing evidence that links neuronal damage with chronic activation of an innate immune response in the central nervous system. The immune system is inextricably involved in the brain development, but also regeneration and repair. This has stimulated therapeutic approaches to modulate the immune system in neurodegenerative diseases. Here, we discuss the current understanding of how astrocytes and microglia shape the neuroimmune responses to drive the pathology neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, polyglutamine (PolyQ) disorders, and the importance of inflammatory responses in the disease progression.

Original languageEnglish (US)
Title of host publicationThe Molecular Immunology of Neurological Diseases
Number of pages9
ISBN (Electronic)9780128219744
StatePublished - Jan 1 2021


  • Alzheimer’s disease
  • Neurodegeneration
  • Neuroinflammation
  • Parkinson’s disease
  • Poly Q repeat disorders

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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