Role of neuronal plasticity after spinal cord injury for neurorobotic control

Anitha Manohar; Robert Davisson Flint; Eric Knudsen; Karen A. Moxon

doi:10.1109/NER.2011.5910603

Role of neuronal plasticity after spinal cord injury for neurorobotic control

Anitha Manohar^*, Robert Davisson Flint, Eric Knudsen, Karen A. Moxon

^*Corresponding author for this work

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

The design of a brain machine interface for the restoration of lower limb control after spinal cord injury involves the restoration of cortical control of the spinal circuits responsible for this movement. However little is known about how these cortical circuits are modified by spinal cord injury. For this purpose we trained rats to perform a skilled hindlimb task and examined how the activity of the neurons in the hindlimb cortex encodes this movement. In this paper we used a method to quantitatively measure the amount of information encoded by the neuronal ensembles about the specific kinematics of movement. Our results show that the cortical firing patterns can encode for intention to move with or without actual limb movement, before and after a complete spinal transection.

Original language	English (US)
Title of host publication	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Pages	534-537
Number of pages	4
DOIs	https://doi.org/10.1109/NER.2011.5910603
State	Published - Jul 20 2011
Event	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011 - Cancun, Mexico Duration: Apr 27 2011 → May 1 2011

Other

Other	2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011
Country/Territory	Mexico
City	Cancun
Period	4/27/11 → 5/1/11

ASJC Scopus subject areas

General Neuroscience

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10.1109/NER.2011.5910603

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title = "Role of neuronal plasticity after spinal cord injury for neurorobotic control",

abstract = "The design of a brain machine interface for the restoration of lower limb control after spinal cord injury involves the restoration of cortical control of the spinal circuits responsible for this movement. However little is known about how these cortical circuits are modified by spinal cord injury. For this purpose we trained rats to perform a skilled hindlimb task and examined how the activity of the neurons in the hindlimb cortex encodes this movement. In this paper we used a method to quantitatively measure the amount of information encoded by the neuronal ensembles about the specific kinematics of movement. Our results show that the cortical firing patterns can encode for intention to move with or without actual limb movement, before and after a complete spinal transection.",

author = "Anitha Manohar and Flint, {Robert Davisson} and Eric Knudsen and Moxon, {Karen A.}",

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doi = "10.1109/NER.2011.5910603",

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Manohar, A, Flint, RD, Knudsen, E & Moxon, KA 2011, Role of neuronal plasticity after spinal cord injury for neurorobotic control. in 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011., 5910603, pp. 534-537, 2011 5th International IEEE/EMBS Conference on Neural Engineering, NER 2011, Cancun, Mexico, 4/27/11. https://doi.org/10.1109/NER.2011.5910603

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AB - The design of a brain machine interface for the restoration of lower limb control after spinal cord injury involves the restoration of cortical control of the spinal circuits responsible for this movement. However little is known about how these cortical circuits are modified by spinal cord injury. For this purpose we trained rats to perform a skilled hindlimb task and examined how the activity of the neurons in the hindlimb cortex encodes this movement. In this paper we used a method to quantitatively measure the amount of information encoded by the neuronal ensembles about the specific kinematics of movement. Our results show that the cortical firing patterns can encode for intention to move with or without actual limb movement, before and after a complete spinal transection.

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Role of neuronal plasticity after spinal cord injury for neurorobotic control

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