Role of nitric oxide in the anticonvulsive effect of progesterone

Taha Gholipour, Atieh Jabbarzadeh, Kiarash Riazi, Aylar Rasouli, Behtash Ghazi Nezami, Mohammad Sharifzadeh, Ahmad Reza Dehpour*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Described here is an investigation of the potential interaction of the nitric oxide signaling pathway with the anticonvulsant effects of progesterone. In ovariectomized Swiss mice, the threshold for seizures induced by intravenous infusion of pentylenetetrazole was determined after treatment with progesterone (25, 50, or 75 mg/kg, given subcutaneously 6 h before seizure testing) or vehicle. Progesterone induced significant anticonvulsive activity at moderate (50 mg/kg) and high (75 mg/kg) doses. This effect of progesterone was abolished by the NO precursor compound l-arginine (200 mg/kg). Moreover, when subeffective doses of progesterone (25 mg/kg) and the NO synthase inhibitor Nω-nitro-l-arginine methyl ester (10 mg/kg) were injected, a strong anticonvulsant effect was observed. These findings suggest a potential role for NO signaling as an anticonvulsant target in females.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalEpilepsy and Behavior
Issue number4
StatePublished - Nov 2008


  • Clonic seizure threshold
  • Estrous cycle
  • Mice
  • Nitric oxide
  • Pentylenetetrazole
  • Progesterone

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


Dive into the research topics of 'Role of nitric oxide in the anticonvulsive effect of progesterone'. Together they form a unique fingerprint.

Cite this