Role of oxidative stress in frontotemporal dementia

Jennifer L. Gerst, Sandra L. Siedlak, Akihiko Nunomura, Rudy Castellani, George Perry, Mark A. Smith*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Recent reports have established oxidative stress and damage as playing a role in the pathogenesis of a number of neurodegenerative diseases including Alzheimer disease, Parkinson disease, corticobasal degeneration, Pick's disease and Alexander's disease. Here we present evidence that oxidative damage is also one of the earliest cytopathological markers of neuronal dysfunction in frontotemporal dementia.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalDementia and Geriatric Cognitive Disorders
Volume10
Issue numberSUPPL. 1
DOIs
StatePublished - 1999

Keywords

  • Cytoskeleton
  • Oxidative stress

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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