Role of progesterone in endometrial cancer

J. Julie Kim, Eloise Chapman-Davis

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

Progesterone is a key hormone in the endometrium that opposes estrogen-driven growth. Insufficient progesterone will result in unopposed estrogen action that could lead to the development of endometrial hyperplasia and adenocarcinoma. Although these endometrial neoplasias can regress in response to progestin treatment, this does not occur in all instances. To understand this resistance to progesterone and to improve on existing hormonal therapies, it is imperative that the molecular mechanisms of progesterone action through its receptor be deciphered in endometrial cancer. This review highlights what is known thus far regarding the efficacy of progestin therapy in the clinic and the role of progesterone in endometrial cancer cell behavior and gene regulation.

Original languageEnglish (US)
Pages (from-to)81-90
Number of pages10
JournalSeminars in reproductive medicine
Volume28
Issue number1
DOIs
StatePublished - Feb 15 2010

Keywords

  • Endometrial cancer
  • Progesterone
  • Progesterone receptor
  • Uterus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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