Role of retrosplenial cortex in processing stress-related context memories

Kevin A. Corcoran, Naoki Yamawaki, Katherine Leaderbrand, Jelena Radulovic*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This work summarizes evidence for the role of RSC in processing fear-inducing context memories. Specifically, we discuss molecular, cellular, and network mechanisms by which RSC might contribute the processing of contextual fear memories. We focus on glutamatergic and cholinergic mechanisms underlying encoding, retrieval, and extinction of context-dependent fear. RSC mechanisms underlying retrieval of recently and remotely acquired memories are compared to memory mechanisms of anterior cortices. Due to the strong connectivity between hippocampus and RSC, we also compare the extent to which their mechanisms of encoding, retrieval, and extinction show overlap. At a theoretical level, we discuss the role of RSC in the framework of systems consolidation as well as retrieval-induced memory modulation. Lastly, we emphasize the implication of these findings for psychopathologies associated with neurological and psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)388-395
Number of pages8
JournalBehavioral Neuroscience
Volume132
Issue number5
DOIs
StatePublished - Oct 2018

Keywords

  • Context memory
  • Local field potential
  • Muscarinic
  • NMDA
  • Retrosplenial cortex

ASJC Scopus subject areas

  • Behavioral Neuroscience

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